丈夫对妻子供肾移植临床分析  

Clinical analysis of husband as donor kidney transplantation

作　　者：王振璞 曲青山[1] 苗书斋[1] 张彦选[1] 

机构地区：[1]郑州人民医院器官移植科,郑州450003

出　　处：《医药论坛杂志》2011年第20期82-84,共3页Journal of Medical Forum

基　　金：郑州市科技发展计划项目(083SGYS33238-3)

摘　　要：目的总结丈夫对妻子供肾移植的临床经验,分析临床效果。方法回顾性分析郑州人民医院器官移植科于2002年4月至2010年12月期间10例丈夫对妻子供肾移植的临床及术后随访资料。所有供者均为男性,年龄平均(48.0±6.7)岁,婚龄平均(24.6±6.0)年,身体健康,供肾切取术均采用开放式手术,3例切取右肾,7例切取左肾;受者年龄平均(48.1±7.3)岁,术后采用三联免疫抑制方案。结果供者情况:手术成功率100%,供者均未发生手术相关并发症,术后平均住院时间为(9.8±1.0)d,术后9天时复查血肌酐平均为(99.4±12.0)μmol/L,低于正常值140μmol/L。术后随访平均(21.5±16.0)月,供者尿蛋白、血肌酐、血压均在正常范围。受者情况:术中开放血液循环后,移植肾开始分泌尿液时间平均(2.7±1.5)min,术后前3d 24h平均尿量分别为(9731±1155.8)ml、(9759±810.4)ml和(9386±569.2)ml,术后前3d血肌酐平均值分别为(323.6±122.7)μmol/L、(135.3±37.2)μmol/L和(88.6±23.1)μmol/L,移植肾功能恢复至正常时间平均为(2.3±0.9)d。所有受者术后均未出现急性排斥反应、移植肾功能延迟恢复及泌尿系等并发症,术后随访时间平均(21.5±16.0)个月。目前为止无1例发生急性排斥反应,肾功能均稳定在正常水平,10例患者人/肾存活率为100%。结论丈夫对妻子供肾移植安全可行,临床效果良好,可作为活体肾移植的常规选择,以缓解供肾紧缺现状并缩短尿毒症患者等待移植时间。Objective To summarize the clinical experience of kidney transplantation husband as donor and analyze the clinical outcome.Methods A retrospective analysis the clinical data as well as follow-up materials of 10 cases of kidney transplantations husband as donor from the Department of Organ Transplantation,People＇s Hospital of Zhengzhou in April 2002 to December 2010.All donors were male,age（48.0±6.7） years on average,marriageable age（24.6±6.0） years on average,healthy.ALL nephrectomies were done by open surgery with 7 left kidneys and 3 right kidneys donated.Recipients,aged（48.1±7.3） years on average,triple-combined anti-rejection therapy post operation was performed with Cyclosporine A（or tacrolimus）,Mycophenolate Mofeti and Prednisone.Results Donor： All donors no surgical complications occurred.The average hospital stay was（9.8 ± 1.0） days.The average serum creatinine of All the donors was（99.4±12.0） μmol/L after 9 days,lower than normal 140μmol / L.All donors were followed up（21.5±16.0） months on average.The protein in urine,serum creatinine and blood pressure were normal of all donors through the whole follow-up.Recipients： The kidney began to secrete urine within（2.7±1.5） minutes on average after blood circulation was reconstruct.The urine volume respectively was（9731±1155.8） ml,（9759±810.4） ml and（9386±569.2） ml on average after 3 days,the serum creatinine respectively was（323.6±122.7） μmol / L,（135.3±37.2） μmol / L and（88.6±23.1） μmol / L on average after 3 days,renal function returned to normal time is 1-4 days,the average（2.3±0.9） days.All recipients no acute rejection,delayed graft function and urinary complications occurred.The average follow-up time（21.5±16.0） months.So far no acute rejection occurred during follow-up.All patients / graft survival rate was 100%.Conclusions Renal transplantation of husband as donor is safe and feasible,has good outcomes and can be used as an option of living donor kidney transplant

关 键 词：肾移植 夫妻 活体肾移植 

分 类 号：R692[医药卫生—泌尿科学]