妊娠糖尿病家族遗传模式及遗传度的研究  

Study of the Heritability and the Hereditary Model of Gestational Diabetes Mellitus

作　　者：高申[1,2] 张蕊[3] 焦振山[4] 

机构地区：[1]天津医科大学公共卫生学院,300070 [2]天津市疾病预防控制中心预防医学杂志社 [3]天津医科大学研究生院流行病学与统计学专业2010级 [4]天津市中医药研究院附属长征医院中心实验室

出　　处：《中国慢性病预防与控制》2011年第6期604-605,共2页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：目的探讨妊娠糖尿病(GDM)的遗传模式和遗传度。方法选择20个GDM先证的家庭成员,利用流行病学和遗传学方法进行询问调查,包括对家族中有糖尿病(DM)患者的一、二级亲属糖尿病发病年龄、病程发展、治疗方法及并发症等的调查。结果 GDM的遗传模式与多基因遗传模式接近,GDM的遗传度为(74.88±10.16)%。结论发生GDM的孕妇本人以及家族成员身上可能存在多个DM相关基因;遗传因素对于GDM的发生有重要作用,但不是唯一的危险因素。Objective To explore the heritability and the hereditary model of gestational diabetes mellitus （GDM） in families of probands. Methods Twenty families of GDM probands were selected. The relative information of them, including age of onset, course of disease, therapy methods and complications of diabetes in probands＇ families, were investigated. Results The hereditary model of GDM closed to polygene pattern. The heritability of GDM was （74.88±10.16）%. Conclusion There might be some relative genes in the bodies of gravidas and their family members. Heredity plays a very important role in the incidence of GDM, but it isn＇ t the unique risk factor.

关 键 词：妊娠糖尿病 遗传模式 遗传度 

分 类 号：R587.1[医药卫生—内分泌]