血清胱抑素C在妊娠期高血压疾病中的应用  

The application of serum Cystatin C in hypertensive disorders of pregnancy

作　　者：侯卫萍[1] 程兰[1] 黄立[1] 

机构地区：[1]天津市中心妇产科医院产科,天津300100

出　　处：《中国计划生育和妇产科》2011年第6期33-35,共3页Chinese Journal of Family Planning & Gynecotokology

摘　　要：目的 探讨胱抑素C(serum Cystatin C,Cys C)在妊娠期高血压疾病(hypertensive disorders of pregnancy,HDP)早期肾损害的应用价值。方法 收集HDP患者和正常晚期妊娠孕妇血清,测定CysC、肌酐(serum creatinine,Scr)、尿酸(uric acid,UA)、尿素氮(Urea),计算肌酐清除率(creatinine clearance rate,CCr)。结果 ①Urea、Scr、UA、CCr水平,妊娠期高血压、轻度子痫前期及慢性高血压合并子痫前期3组与重度子痫前期及正常组比较差异有统计学意义(P<0.05),3组间比较差异无统计学意义(P>0.05);②CysC水平各组不同,组间比较均有统计学意义(P<0.05)。结论 血清CysC水平可敏感、准确地反映HDP患者早期肾损害。Objective To study the diagnosis value of serum Cystatin C（Cys C） in early renal injury of hypertensive disorders of pregnancy（HDP）. Methods The data about blood urea （Urea）, creatinine （Scr）, uric acid（ UA）, Cystatin C（ Cys C） of serum from HDP cases and normal gravida in late pregnancy were detected and the creatinine clearance rate （CCr） were calculated. Results Comparing with the normal and severe preeelampsia, Urea, Scr, UA level in gestational hypertension, mild preeelampsia and preeclampsia complicating chronic hypertension groups were increased, and CCr level was decreased, the difference was statistically significant （ P 〈 0.05） among gestational hypertension, mild preeclampsia, and preeclampsia complicating chronic hypertension to normal and severe preeclampsia group respectively, but there was not statistical significance of difference among the three groups（P 〉 0. 05 ）. While Cys C level was different in the five groups, and there was statistically significant （P 〈 0. 05 ） among each of them. Conclusion Cys C is sensitive, exactly index to reflex exarly kidney damage in HDP cases.

关 键 词：胱抑素C 妊娠期高血压疾病 肾损害 

分 类 号：R714.25[医药卫生—妇产科学]