抗CCP抗体与RF联合检测诊断类风湿关节炎的意义  

The anti-CCP antibody united the examination with the kind of the RF to diagnose rheumatoid arthritis

作　　者：韩文明[1] 

机构地区：[1]中国航天科技集团公司七三八疗养院医疗部检验科,无锡214081

出　　处：《中国现代医药杂志》2011年第12期54-56,共3页Modern Medicine Journal of China

摘　　要：目的探讨抗环瓜氨酸肽抗体(抗CCP抗体)与类风湿因子(RF)联合检测诊断类风湿关节炎(RA)的意义。方法用酶联免疫吸附试验(ELISA)法检测抗CCP抗体,胶乳增强免疫比浊法定量检测RF。结果 155例RA患者抗CCP抗体阳性104例,阳性率67.1%,RF阳性109例,阳性率70.3%;126例非RA患者抗CCP抗体阳性6例,阳性率4.76%,RF阳性35例,阳性率27.8%;抗CCP抗体对RA诊断的敏感性为66.6%,特异性为94.8%;RF对RA诊断的敏感性为70.3%,特异性为70.8%;抗CCP抗体或RF某一项阳性时对RA诊断的敏感性为82.6%,特异性为75.3%;抗CCP抗体和RF联合检测时对RA诊断的敏感性为75.1%,特异性为99.1%。抗CCP抗体对RA诊断的敏感性低于RF,两者比较差异无统计学意义(χ2=0.317,P>0.05);但特异性高于RF,两者比较差异具有统计学意义(χ2=20.22,P<0.01)。结论用ELISA法检测抗CCP抗体,操作简单,不需要特殊设备,和RF检测一样对RA诊断均具有较好的敏感性和特异性,但抗CCP抗体的检测对RA的诊断更具有高度的特异性,两者联合检测可提高RA诊断的准确性。Objective To discuss the anti cyclic citrullinated peptide antibody （the anti-CCP antibody） united the examination with the kind of rheumatoid factor （RF） to diagnose rheumatoid arthritis（RA）. Methods United the enzyme linked immunosorbent assay （ELISA） with the enzyme to examine the anti-CCP antibody, the rubber latex enhancement immunity turbidi- metric method quota examines RF. Results 155 example RA patients anti-CCP antibody masculine gender 104 examples, masculine gender rate 67.1%, RF masculine gender 109 examples, masculine gender rate 70.3%; 126 example non-RA patients an- ti-CCP antibody masculine gender 6 examples, masculine gender rate 4.76%, RF masculine gender 35 examples, masculine gen- der rate 27.8%. The anti-CCP antibody to the RA diagnosis＇s sensitivity was 66.6%, the specificity was 94.8%; RF to the RA di- agnosis＇s sensitivity was 70.3%, the specificity was 70.8%. Anti-CCP antibody or RF some masculine gender to the RA diagno- sis＇s sensitivity was 82.6%, the specificity was 75.3%. Anti-CCP antibody and RF union examination to the RA diagnosis＇s sen- sitivity was 75.1%, the specificity was 99.1%.The anti-CCP antibody was lower than RF to the RA diagnosis＇s sensitivity, both comparison difference non-statistics significance （χ2=0.317, P〉0.05）. But the specificity was higher than RF, both comparison difference had statistics significance （χ2=20.22, P〈O.O1）. Conclusion Examines the anti-CCP antibody with the ELISA, the simplicity of operator, does not need the specific installation, has the good sensitivity and the specificity equally with the RF ex- amination to the RA diagnosis, but the anti-CCP antibody＇s examination has the high specificity to the RA diagnosis, both union examination may enhance the accuracy of the RA diagnosis, is worth the clinical promoted application.

关 键 词：抗环瓜氨酸肽抗体 类风湿因子 类风湿关节炎 

分 类 号：R593.22[医药卫生—内科学]