miRNA在心脏发育和心血管疾病中的研究进展  

The role of miRNA in the development of heart and cardiovascular diseases

作　　者：巩丽颖[1,2] 邱广蓉[1] 孙开来[1] 

机构地区：[1]中国医科大学基础医学院医学遗传学教研室,沈阳110001 [2]辽宁省人民医院检验科,沈阳110016

出　　处：《国际遗传学杂志》2011年第6期311-318,332,共9页International Journal of Genetics

基　　金：国家自然科学基金（81070131;30400485）

摘　　要：miRNA是内源性非编码微小RNA，长度约22个核苷酸。愈是高等生物，miRNA数量愈多,这可能是高等生物生命多样化的原因之一。而且，在不同物种之间，其序列高度保守。miRNA通过调控靶基因表达参与调控多种生物学过程，并且与疾病发生发展密切相关。近来的研究证实，miRNA广泛参与心脏发育和心血管疾病发生发展。本综述将总结miRNA在心血管发育中的作用以及在心脏疾病中的作用机制，探讨目前的miRNA的研究策略，以及miRNA作为诊断标记物和药物治疗靶点的可能性。miRNA is a type of endogenous, non-coding small RNA, and about 22nt long. The more evolved the creature is, the larger the number of miRNA, which might be the reason of the complexity of lives. As the same time, the sequence of miRNA is highly conserved among different species. It has been found that miRNA plays important roles in many biological processes and closely related to diseases by regulating target genes. Studies of miRNA indicate that miRNA also function in the process of cardiac development and diseases. This review is to conclude the latest advances in the studies of miRNA associated with development of heart and cardiovascular diseases, to discuss the strategy of syudying miRNA, and to explore their possibility as markers for injury and for potential treatment of deseases.

关 键 词：心脏发育 心血管疾病 微小RNA 

分 类 号：R54[医药卫生—心血管疾病]