TRIB3基因Q84R多态性与2型糖尿病  

The single nucleotide polymorphism of TRIB3 Q84R and type 2 diabetes

作　　者：刘英晓[1] 董春玉[2] 

机构地区：[1]威海市文登中心医院内分泌科,264400 [2]威海市文登中心医院神经内科,264400

出　　处：《国际遗传学杂志》2011年第6期348-351,共4页International Journal of Genetics

摘　　要：TRIB3基因是2型糖尿病及糖尿病动脉粥样硬化的易感基因之一，其基因多态性Q84R与2型糖尿病有强相关性，这一结果在白种人中已得到证实。TRIB3基因位于人染色体20p13-P12．2，蛋白质位称TRB3，该基因通过抑制丝氨酸／苏氨酸蛋白激酶Akt的磷酸化，抑制胰岛素信号传导，而在糖代谢中起重要作用。另外，有研究认为TRIB3基因可能调节胰腺β细胞功能。By far the most spectacular development in the field of muhifactorial type 2 diabetes genetics has been the identification of Tribbles homolog 3-Drosophila （ TRIB3 ） . It is one of the most important susceptibility gene of type 2 diabetes and atheroselerosis with diabetes. Common variants in the gene that encodes Q84R have been strongly associated with type 2 diabetes. The result has been proved in white groups, but the study of TRIB3 Q84R is just started in China. The TRIB3 gene is on chromosome 20p12.2-p13 and encodes protein TRB3. The gene plays an important role in glucose metabolism by suppressing the phosphorylation of serine-threonine kinase and the conduction of insulin signals. In addition , TRIB3 may regulate the function of pancreas 13-cells.

关 键 词：TRIB3基因 单核苷酸多态性 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]