多氯联苯分子遗传毒性和流行病学研究进展  

Advances in genetic toxicity study and epidemiology of polychlorinated

作　　者：宋鹏[1] 吴南翔[1] 

机构地区：[1]浙江省医学科学院卫生学研究所,杭州310013

出　　处：《国际流行病学传染病学杂志》2011年第6期429-432,I0001,共5页International Journal of Epidemiology and Infectious Disease

基　　金：浙江省科技计划重大项目（2008C03001-1）

摘　　要：多氯联苯（PCBs）是一类在环境中广泛存在的持久性有机污染物，对生物体具有蓄积毒性。研究表明PcBs表现出的分子遗传毒性能够引起神经系统、内分泌系统、生殖系统等相关基因表达的显著调节。低等动物、模型动物及啮齿类动物被大量应用于研究PCBs对分子和细胞功能相关基因及生理发育功能相关基因的影响。目前，对于PCBs人群流行病学的研究多集中于部分疾病易感基因，如细胞色素P450、癌基因等。对PCBs分子遗传毒性的探讨对于阐释其遗传毒性机制具有深刻的意义，此文就PCBs的分子遗传毒性及流行病学研究进展作一综述。Polychlorinated biphenyls （PCBs） is a kind of extensively existed persistent organic pollutants （POPs） in the environment, which can cause accumulative poisonous effects to organism. Many studies indicated that PCBs have molecular genetic toxicity, which can cause significant regulation of related genes on nervous system, endocrine system and genital system. Lower animals, model animals and rodent animals have been widely used to study the related genes of molecular, cellular, physiological and developmental function. The epidemiologic studies of PCBs mainly focused on partial disease susceptible genes such as cytochrome P450 gene and oncogene. It＇s deeply meaningful and worth further study to investigate the molecular genetic toxicity of PCBs and illustrate its mechanism, the research advances of the molecular genetic toxicity and epidemiologic study of PCBs are reviewed.

关 键 词：多氯联苯化合物 分子遗传毒性 基因 流行病学 

分 类 号：R114[医药卫生—卫生毒理学]