高效抗反转录病毒治疗预防HIV母婴传播效果的综合评价  

A comprehensive evaluation for the efficacy of HAART for prevention of HIV transmission by maternal-neonate

作　　者：庞俊[1] 黄绍标[2] 刘冬梅[1] 韦淑珍[1] 黄金萍[1] 

机构地区：[1]广西南宁市第四人民医院产科,广西南宁530023 [2]广西南宁市第四人民医院感染科,广西南宁530023

出　　处：《右江民族医学院学报》2011年第6期746-749,共4页Journal of Youjiang Medical University for Nationalities

基　　金：广西壮族自治区卫生厅科研课题(No.Z2009014)

摘　　要：目的了解孕期孕产妇人免疫缺陷病毒（HIV）感染途径与相关危险行为，并对孕期接受高效抗反转录病毒治疗（HAART）预防HIV母耍传播的效果进行综合评价。方法采用非概率抽样法调查孕产妇的社会人口学特征、相关危险行为、HIV感染途径及其配偶伺定性伴的HIV感染情况；对HIV感染的孕妇在孕期给予HAART，耍儿出生后4～6周和4个月分别进行HIV-1DNA检测，12-18个月进行HIV抗体检测，判断晏儿的HIV感染情况。结果HIV感染孕产妇经性传播途径感染比例高达84．56％，其中非婚异性性行为途径感染占58．26％，家庭内性传播占41．74％，有31．62％的配偶伺定性伴HIV抗体阴性；随访至2011年6月，有129例耍儿年满12～18个月，HIV抗体检测结果全部阴性，现阶段HIV母要传播率为0。结论非婚性行为是性途径传播的主要影响因素、家庭内配偶徊定性伴间的传播不容忽视。规范的HAART结合安全分娩和人工喂养，可以达到联合国大会提出的消除母耍传播艾滋病病毒的目标。Objective To study the women in pregnancy who received highly active antiretroviral therapy （HAART） for preventing of HIV transmission by maternalneonate, then to make a comprehensive evaluation for the efficacy of HAART on prevention of HIV maternal - neonatal transmission, meanwhile the relative risk behaviors were also studied. Methods The nonprobability sampling was used to survey the women in pregnancy on their features of social demography, the relative risk behaviors, HIV transmission and the infected condition of their spouses/regular sex partners. The HIV infected women in pregnancy were given HAART. HIV infected patients in pregnancy received HAART, then HIV- 1 DNA tests were performed for infants aged 4 - 6 weeks and 4 months, respectively. HIV antibody tests were performed for infants aged 12-18 months to confirm whether the infants were infected HIV. Results For the HIV infected women in pregnancy, the infection rate of sexual transmission reached to 84.56 %, of which extra - marital sexual behavior accounted for 58.26 %, and family sexual transmission for 41.74 %, while 31.62 % spouses/regular sex partners got negative HIV antibody. The follow - up ended in June 2011, HIV antibody tests for 129 infants aged 12 to 18 months all resulted in negative HIV antibody. By now the rate of maternal- neonatal transmission had been zero. Conclusion Extra - marital heterosexuality was the main influential factor in sexual transmission. However, family spouses/regular sex partners transmission shouldn＇ t be ignored. It＇s possible to achieve the goal of eliminating HIV transmission by maternal- neonate, which was proposed by the United Nations General Assembly, by regular HAART plus safe labor and artificial feeding.

关 键 词：人免疫缺陷病毒 获得性免疫缺陷综合征 抗逆转录病毒治疗 高效 母婴传播阻断 

分 类 号：R512.91[医药卫生—内科学]