小而密低密度脂蛋白与冠心病的相关性研究  

Relationship between small,dense low-density lipoprotein and coronary heart disease

作　　者：翟菊萍[1] 黄惠芳[1] 顾国浩[1] 周滔[2] 金晓华[1] 邱骏[1] 

机构地区：[1]苏州大学附属第一医院检验科,江苏苏州215006 [2]江苏大学基础医学与医学技术学院,江苏镇江212013

出　　处：《中国现代医学杂志》2011年第27期3376-3379,共4页China Journal of Modern Medicine

基　　金：江苏省厅"科教兴卫工程"医学重点学科开放性课题(No:xk200723)

摘　　要：目的探讨血清小而密低密度脂蛋白(sdLDL)水平与冠心病(CHD)发生发展的关系。方法选取冠心病患者105例作为病例组,包括稳定性心绞痛(SAP)组36例、不稳定性心绞痛(UAP)组39例和急性心肌梗死(AMI)组30例。另取30例体格检查正常,一般资料与病例组相匹配的体检者为对照组,测定各组血清sdLDL水平并进行比较。同时将SAP、UAP、AMI组的sdLDL与冠心病冠脉狭窄程度(Gensini评分)进行相关性分析。结果冠心病组sdLDL水平较对照组明显增高(P<0.05),有统计学意义。SAP、UAP、AMI各组sdLDL水平与对照组比较,均明显增高(P<0.05)。SAP,UAP,AMI组间两两比较无统计学差异(P>0.05)。三组患者sdLDL与冠脉狭窄程度(Gensini积分)相关性:SAP患者sdLDL水平与冠脉狭窄程度(Gensini积分)无明显相关性。UAP,AMI患者的sdLDL水平与冠脉狭窄程度(Gensini积分)成明显正相关。结论研究结果显示sdLDL升高是发生冠心病的一个重要因素,sdLDL对于预测有无冠状动脉病变及其病情进展有一定临床意义。[Objective] To investigate the relationship between the serum level of small dense low-density lipoprotein （sdLDL） with coronary heart disease. [Methods] A total of 105 patients with coronary heart disease without hypertension and smoking history as the coronary heart disease （CHD） group, were divided into 3 groups, including the stable angina pectoiis （SAP） group （36 cases）, the unstable angina pectoris （UAP） group （39 eases） and the acute myocardial infarction （AMI） group （30 cases）, another 30 patients with normal coronary angiograpby served as control group （30 cases）. The serum sdLDL was detected using the two-point end assay. Meanwhile the severity of coronary artery stenosis was quantautively assessed by Gensini score. [ Results ] The level of sdLDL in all the CHD groups was higher than that in control group （P 〈0.05）. The severity of coronary artery stenosis defined by Gensini score was positively correlated with the sdLDL level in UAP and AMI group, but not in SAP group. [ Conclusions] These date suggested increased sdLDL plays a major role in the development of coronary disease and sdLDL can be a valuable index for the diagnosis and progress of CHD.

关 键 词：冠心病 稳定性心绞痛 不稳定性心绞痛 急性心肌梗死 小而密低密度脂蛋白 

分 类 号：R543[医药卫生—心血管疾病]