社区获得性肺炎患者血液可溶性P-选择素与C反应蛋白、白细胞、血小板间关系的临床分析  

Clinical analysis of the relationships between the plasma P-selectin concentration with c-reactive protein,white blood cell and platelet in community-acquired pneumonia

作　　者：万御易[1] 朱述阳[1] 陈玉玲[1] 

机构地区：[1]徐州医学院附属医院呼吸科,江苏徐州221002

出　　处：《中国现代医学杂志》2011年第27期3447-3450,共4页China Journal of Modern Medicine

摘　　要：目的探讨成人社区获得性肺炎(CAP)病人血浆可溶性P-选择素(soluble P-selectin,sPs)浓度的演变趋势,结合炎症指标CR P、WBC、PLT的变化,了解sPs的临床作用。方法观察对象分为三组;A组,为36例CAP并发继发性血小板增多症(secondary thrombocytosis,ST)病人;B组,为36例无ST的CAP病人,分别检测A组和B组观察对象五次的sPs、CRP、WBC、PLT的数值,即入院时0 h、24 h、48 h、72 h和痊愈出院时;C组,为对照组,180例健康成人,分别检测一次的sPs、CRP、WBC和PLT。结果 A组并发有ST的CAP病人sPs、CR P、WBC、PLT均较B组无ST的CAP病人高,差异有统计学意义(P<0.01),四项指标间有正相关关系,sPs与CRP相关性最好。结论结合CRP、WBC、PLT等炎症指标,连续检测CAP病人血浆sPs浓度,对CAP病人病情的判断、治疗和预后有重要的临床价值。[ Objective ] To understand the Soluble P-selectin clinical effects, and analyse the evolution tendency of the plasma soluble P-sclectin （sPs） concentration of adult community-acquired pneumonia （CAP） patient. The inflammatory biomarkers changes of the CRP, the WBC and the PLT were analyzed at the same time. [ Methods ] The study population was 72 patients with CAP and 180 healthy persons, were divided into 3 groups： A, CAP with ST （n =36） and B, CAP simply （n =36）, the sPs, the CRP, the WBC and the PLT were detected when the patients were admitted, and 24 h, 48 h, 72 h later, and the patients recovered to discharge; C, control group, the healthy （n =180）, the sPs, the CRP, the WBC and the PLT were detected once. [Results] The sPs, the CRP, the WBC and the PLT of the patients with ST were highest than the other two groups, have very significant difference （P 〈0.01） between them. There are positive correlation in the four indexes, the best correlation is between the sPs and the CRP. [ Conclusion] Combined with the inflammation biomarkers including CRP, WBC and PLT, continuous detecting the concentration of the sPs, may have very important clinical value in the judgment ,the treatment and the prognosis of the CAP patients.

关 键 词：社区获得性肺炎 继发性血小板增多症 可溶性P-选择素 C反应蛋白 

分 类 号：R563[医药卫生—呼吸系统]