2型糖尿病患者颈动脉内中膜厚度与血管内皮功能的相关性研究  

Correlation study of the carotid intima - media thickness and vascular endothelial function in patients with type 2 diabetes mellitus

作　　者：陈宇 裴中美 

机构地区：[1]上海市青浦区中医医院超声科,201700 [2]上海市青浦区中医医院内科,201700

出　　处：《中国实用医刊》2011年第24期6-8,共3页Chinese Journal of Practical Medicine

摘　　要：目的应用高频超声检测2型糖尿病患者的颈动脉内中膜厚度（IMT）和血管内皮功能的变化及两者的相关性。方法采用高频超声检测56例2型糖尿病患者及30例健康人颈动脉IMT、肱动脉反应性充血后内径变化率（EDD）及舌下含服硝酸甘油后内径变化率（EID），并进行相关分析。结果2型糖尿病伴合并症组颈动脉IMT值高于单纯2型糖尿病无并发症组（P〈0．05）；单纯2型糖尿病无并发症组颈动脉IMT值又高于对照组，但差异无统计学意义；单纯2型糖尿病组、糖尿病伴合并症组肱动脉EDD明显低于对照组（P〈0．01）。2型糖尿病伴合并症组EDD低于单纯糖尿病组（P〈0．05）。各组间EID比较差异无统计学意义（P〉0．05）。结论高频超声可以在糖尿病患者出现血管结构改变之前发现内皮功能损害情况，EDD及IMT可作为监测及评价糖尿病大血管病变的指标。Objective To investigate the relationship between the carotid intima -media thick- ness（IMT） and vascular endothelial function in patients with type 2 diabetes mellitus （DM）by high frequency sonography. Methods The IMT and changes of brachial artery internal diameter under the reactire hyperemia situation （EDD） or after sublingual nitroglycerin （ EID ） in 56 patients with DM and 30 healthy subjects were measured and their relationship was analyzed. Results IMT in type 2 DM with complications was significantly higher than that of pure DM without complications （ P 〈 0.05 ） , IMT in pure DM without complications was higher than that of normal control group, but there was no significant difference between them. The increased percentage of the brachial artery diameter under reactive hyperemia （EDD） in pure type 2 DM and DM with complications group was significantly lower than that of control group （P 〈 0. 01 ）. The EDD in DM with complications group was lower than that of control group （ P 〈 0. 05 ）. And also there was no significant difference in EID between the above groups （P 〉 0. 05）. Conclusions The decrease of vascular endothelial function can be detected in DM by high frequency sonography before the structural change. EDD and IMT can be used to monitor and provide evidence of the vascular condition of DM.

关 键 词：糖尿病 颈动脉 内皮功能 高频超声 内中膜厚度 

分 类 号：R587.1[医药卫生—内分泌]