辛伐他汀对代谢综合征并良性前列腺增生患者下尿路症状的影响  

Effects of simvastatin on lower urinary tract symptoms in patients with metabolic syndrome coexisting with benign prostate hyperplasia

作　　者：林秀芳[1] 徐原宁[1] 曹立[2] 董碧蓉[1] 

机构地区：[1]四川大学华西医院老年干部科,成都610041 [2]四川大学华西医院心脏科,成都610041

出　　处：《中华老年医学杂志》2011年第12期1018-1020,共3页Chinese Journal of Geriatrics

摘　　要：目的观察辛伐他汀对代谢综合征（MS）并存良性前列腺增生症（BPH）患者的下尿路症状（LUTS）影响。方法2011年26月我科门诊和住院患者中MS并存BPH继发LUTS患者共30例，检查并记录国际前列腺症状评分（IPSS）、生活质量评分（QOL）、最大尿流率（MFR）、前列腺体积、肝肾功能、尿常规后，随机分为两组：联合用药组给予辛伐他汀40mg和坦索罗辛0．2mg口服，每晚1次；单药组给予坦索罗辛0．2mg口服，每晚1次，治疗8周后复诊，复查上述指标，对治疗的有效性和安全性进行评价。结果联合用药组和单药组IPSS、QOL、和MFR与治疗前比较，差异均有统计学意义，前列腺体积差异无统计学意义。联合用药组治疗后IPSS评分变化值为（6．4±4．4）分，单药组为（4．2±3．3）分，两组比较差异有统计学意义（P〈0．05），联合用药组症状改善优于单药组。两组均无不良事件发生。结论辛伐他汀对MS并存BPH患者的LUTS有改善作用，联合用药组耐受性良好，未出现明显不良事件。Objective To determine whether simvastatin alleviates lower urinary tract symptoms （LUTS） in patients with metabolic syndrome （MS） coexisting with benign prostate hyperplasia （BPH） and explore an optimized scheme of treatment. Methods From February to June in 2011, 30 male subjects with MS and LUTS caused by BPH in out-patients and in-patients from geriatric department were recruited. The patients were randomly assigned to receive orally simvastatin （40 mg） and tamsulosin （0.2 rag） quaque nocte as combination treatment group or only tamsulosin （0.2 mg, quaque nocte） as single treatment group for 8 weeks. International prostate symptoms score （IPSS）, quality of life （QOL）, maximum flow rate （MFR） and prostate volume （PV）, liver enzymes, creatinine and routine urine test were monitored to evaluate the effectiveness and safety before and after the treatment. Results In the two groups, the significant differences were found in the levels of IPSS, QOL and MFR, while there was no difference in PV between pre-treatment and post-treatment. The scores of IPSS after treatment were （6.4 ±4.4）in combination treatment group and（4.2 ±3.3）in single treatment group （P^0.05）, and there were significant difference in scores of IPSS before and after the treatment between two groups （P〈0.05）, suggesting better improvement in combination treatment group than in single treatment group. In two groups, there were no adverse events, and no changes were found in liver and kidney function, muscle enzymes and routine urine test. Conclusions Combined tamsulosin and simvastatin treatment may alleviate LUTS caused by BPH and are well tolerated with no adverse events.

关 键 词：前列腺增生 代谢综合征X 

分 类 号：R6[医药卫生—外科学] R589[医药卫生—临床医学]