瑞芬太尼对心肌保护作用的研究进展  

Research Progress of Remifentanil for Myocardium Protection Function

作　　者：郭欣[1] GUO Xin （Yunnan Province No.1 People＇s Hospital,Kunming 650032, China）

机构地区：[1]云南省第一人民医院麻醉科,云南昆明650032

出　　处：《医学信息》2011年第23期837-838,共2页Journal of Medical Information

摘　　要：瑞芬太尼具有独特的药代动力学特点．能迅速达到有效血药浓度并在血浆中快速代谢。它可应用于肝肾功能不全和心脏功能下降的患者，同其他阿片类相比较具有围术期心脏保护功能。同时运用瑞芬太尼进行镇痛及镇静治疗．可实现早期复苏、早期脱离呼吸机及早期拔管的目标。为避免由长期的机械通气所引发的并发症提供了有效的支持。Remifentanil has a unique pharmaeokinetic profile, with a rapid onset and offset of action and a plasmatic metabolism. Its use can be recommended even in patients with poor cardiovascular function. A potential protective cardiac preconditioning effect has been suggested. Drug-related adverse effects seem to be comparable with other opioids. In cardiac surgery, many randomized controlled trials demonstrated that the potential benefits of the use of remifentanil not only include a profound protection against intraoperative stressful stimuli, but also rapid postoperative recovery, early weaning from mechanical ventilation, and extubation.

关 键 词：瑞芬太尼 心肌保护 

分 类 号：R971.2[医药卫生—药品;医药卫生—药学]