犬假体腹主动脉瘤的制作  

Creation of a prosthetic abdominal aortic aneurysm in dogs

作　　者：吕瑜环[1] 龚万和 徐在品[1] 马喆[1] 杜培杭[1] 彭尧[1] 邓小燕[3] 孙安强[3] 

机构地区：[1]贵州大学动物科学学院外科,贵州贵阳550025 [2]贵州省职工医院外科,贵州贵阳550025 [3]北京航空航天大学生物与医学工程学院,北京100191

出　　处：《中国普通外科杂志》2011年第12期1327-1330,共4页China Journal of General Surgery

基　　金：国家自然科学基金资助项目(10772054;31170904;11102014)

摘　　要：目的制作犬假体腹主动脉瘤,评价其生物功能性和生物相容性,为腹主动脉瘤的实验研究提供动物模型。方法将2种直径(29,6 mm)的人工血管用0号丝线缝合成梭状假体主动脉瘤植入犬腹主动脉,术后5个月剖检假体动脉瘤,检测其生物功能性和生物相容性。结果模型手术成功率76.9%(10/13),手术全程用时(2±0.5)h,血管吻合时间为(50±12)min。术后5个月,假体腹主动脉瘤血流通畅,瘤体无渗血,腔内无血凝块,表现出良好的生物功能;假体腹主动脉瘤外有组织,内有血管内皮细胞生长,表现出良好的生物相容性。结论本假体腹主动脉瘤具有良好的生物功能性和生物相容性,该模型可用于腹主动脉瘤的实验研究。Objective To create a prosthetic abdominal aortic aneurysm in dogs and then determine its biological function and biocompatibility,so as to provide an animal model for the experimental study of abdominal aortic aneurysm.Methods Two types of artificial blood vessels（29 mm and 6 mm in diameter） were anastomosed with 1-0 suture to fabricate a fusiform prosthetic aneurysm that was then interposed in the abdominal aorta of dog.The biological function and biocompatibility of the graft were detected 5 months after operation.Results The success rate of model establishment was 76.9%（10/13）.he whole operating time was（2±0.5） h,in which the vessel anastomotic time was（50±12） min.Five months later,the blood flow in prosthetic aneurysm was patent,and there was no bleeding in the body or blood clots in the lumen of the prosthetic aneurysm.The outer layer of prosthetic aneurysm was enclosed by soft tissue and the inner layer of the prosthetic aneurysm was covered with vascular endothelial cells.Conclusions This prosthetic abdominal aortic aneurysm has satisfactory biological function and biocompatibility,and this animal model can be used for experimental study of abdominal aortic aneurysm.

关 键 词：主动脉瘤 腹 人工血管 生物功能性 生物相容性 模型 动物 犬 

分 类 号：R654.3[医药卫生—外科学]