透明质酸钠在输卵管介入再通术后预防复发性粘连的临床应用  

Clinical application of sodium hyaluronate in preventing recurrent adhesions of fallopian tube after interventional recanalization

作　　者：何志兵[1] 陈敏[2] 周洲[1] 

机构地区：[1]湖北医药学院附属襄阳医院放射科,湖北襄阳441000 [2]湖北医药学院附属襄阳医院妇产科,湖北襄阳441000

出　　处：《实用放射学杂志》2011年第12期1886-1888,共3页Journal of Practical Radiology

摘　　要：目的 评价透明质酸钠在输卵管介入再通术后预防复发性粘连的临床价值.方法 将169例输卵管阻塞性不孕症患者随机分为对照组（60例）和观察组（109例）,前者行输卵管介入再通术后常规使用松解液（庆大霉素8万u、地塞米松10 mg、α-糜蛋白酶5 g的水溶液40 ml）治疗,后者则在此基础上加用透明质酸钠预防复发性粘连.观察2组术后输卵管再通、复发性粘连发生情况及受孕情况.结果 观察组109例子宫输卵管造影显示输卵管阻塞210条,术后缺如8条,介入再通202条,再通成功率为96.2%（202/210）;对照组60例经子宫输卵管造影显示输卵管阻塞108条,介入再通103条,再通成功率为95.4%（103/108）,2组比较无显著性差异（P＞0.05）.观察组介入再通术后3个月粘连复发率及12个月内受孕率分别为3.7%和57.8%,对照组分别为26.7%和25.0%,2组比较有显著性差异（P＜0.05）.结论 透明质酸钠能有效预防输卵管介入再通术后复发性粘连的发生,具有很好的临床应用价值.Objective To evaluate clinical value of sodium hyaluronate in preventing recurrent adhesions of fallopian tube after in terventional recanalization. Methods 169 patients with sterility caused by fallopian tube obstruction were randomly divided into the control group （60 cases） and the observation group （109 cases）. The former was treated with the routine lysis solution （gentamiein 80 000U, dexamethasone 10mg, a-chymotrypsin 5g, dissolved in 40ml physiological saline solution） after interventional recanaliza tion,and the latter was added on this basis, sodium hyaluronate to prevent recurrent adhesions. Fallopian tube recanalization,the recurrence of adhesions and pregnancy status were observed after interventional tubal recanalization. Results In the observation group, 210 tubes in 109 cases were obstructed,8 tubes missing, 202 tubes were successfully recanalized, the recanalization rate was 96.2 （202/210）;in the control group,108 tubes in 60 cases were obstructed, 103 tubes were successfully recanalized, the recanalization rate was 95.4% （103/108） ,there were no significant differences （P〉0.05） between two groups. In the observation group , recurrent adhesions rate in 3 months and pregnancy rate within 12 months was 3.7% and 57.8% respectively after interventional recanalization;and in the control group, it was 26.7% and 25.0% respectively. Significant difference of recurrent adhesions rate and pregnancy rate consisted between the two groups（P〈0.05）. Conclusion Sodium hyaluronate is effective in preventing recurrent adhesions of fallopian tube after interventional recanalization,and it has a significant clinical value.

关 键 词：输卵管阻塞 不孕症 输卵管再通术 透明质酸钠 复发性粘连 

分 类 号：R711.76[医药卫生—妇产科学] R711.6[医药卫生—临床医学]