益气养阴方联合蚓激酶胶囊防治IgA肾病气阴两虚型临床观察  

Effect of Yiqi Yangyin Decoction United Lumbrokinase Capsule with Qi and Yin Deficiency Type of IgA Nephropathy

作　　者：金周慧 陈月琴 彭文[2] 姚卫国[2] 

机构地区：[1]上海市普陀区利群医院中医科,上海200333 [2]上海中医药大学附属普陀医院肾脏科,上海200062

出　　处：《中华中医药学刊》2011年第12期2822-2824,共3页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:观察益气养阴方联合蚓激酶胶囊治疗IgA肾病气阴两虚型的临床疗效。方法:经肾穿刺活检确诊IgA肾病和中医辨证为气阴两虚型患者50例,对照组(n=25例)用益气养阴方,蚓激酶组(n=25例)用益气养阴方联合蚓激酶胶囊,均治疗6个月。观察临床症状和血液流变学、纤维蛋白原、D-二聚体、u-PA、PAI-1,血清肌酐(Scr),尿红细胞计数、24h尿蛋白量治疗前后的变化情况。结果:两组患者血浆黏度、血小板聚集率、纤维蛋白原、血清肌酐、尿红细胞计数、24h尿蛋白量与治疗前比较均有统计学差异(P<0.05或P<0.01),且两组间临床症状积分、血液流变学、纤维蛋白原的结果比较有统计学差异(P<0.05),蚓激酶组总有效率达96%。结论:益气养阴方联合蚓激酶胶囊能显著改善IgA肾病患者血液流变、降低血尿、蛋白尿,缓解临床症状,对IgA肾病有较好地防治作用。Objective：To observe the effect of Yiqi Yangyin Decoction united lumbrokinase capsules on patients with Qi and Yin Deficiency type of IgA nephropathy. Methods ： The renal biopsy confirmed 50 cases of IgA nephropathy and traditional Chinese physician identified the type of qi and yin deficiency. They were divided into control group （n = 25 patients）, which were treated by Yiqi Yangyin Decoction, and lumbrokinase group （ n = 25 patients）, which were treated by Yiqi Yangyin Decoction united lumbrokinase capsules. All were treated in 6 months and observed the changes of the clinical symptoms, hemorheology, fibrinogen, D - dimer, u - PA, PAI- 1, serum creatinine （ Scr）, urinary red blood cell count, 24 - hour urine protein in pre - therapy and post - therapy. Results ： There were significantly different in plasma viscosity, platelet aggregation rate, fibrinogen, Scr, urine red cell count, 24 - hour proteinuria compare with those before treatment （ P 〈 0.05 or P 〈 0.01 ）, and the results of two groups of clinical symptom score, hemorheology, fibrinogen were statistically significant （P 〈 0.05 ）. Lumbrokinase group total effective rate was 96%. Conclusion： Yiqi Yangyin Decoction united lumbrokinase capsule can improve blood rheology, reduce hematuria and proteinuria, remission clinical symptoms and there are better preventive roles on patients with Qi and Yin Deficiency type of IgA nephropathy.

关 键 词：蚓激酶 IGA肾病 中医 益气养阴方 

分 类 号：R692[医药卫生—泌尿科学]