鹿瓜多肽辅助治疗活动期类风湿关节炎临床观察  

Clinical observation of Lugua polypeptide adjuvant therapy for rheumatoid arthritis in active stage

作　　者：李昌[1] 吴燕生[1] 

机构地区：[1]解放军第175医院(厦门大学附属东南医院)急诊科,福建漳州363000

出　　处：《临床军医杂志》2011年第6期1133-1135,共3页Clinical Journal of Medical Officers

摘　　要：目的探讨鹿瓜多肽注射液辅助治疗活动期类风湿关节炎的临床疗效。方法 108例类风湿性关节炎患者,随机分为治疗组和对照组,治疗组在常规给予双氯芬酸钠缓释片,辅以鹿瓜多肽注射液静滴治疗,而对照组仅服用双氯芬酸钠缓释片,观察两组治疗前后相关临床及实验室指标变化。结果经过3周治疗,两组患者晨僵时间、关节肿胀指数、关节压痛指数和红细胞沉降率较治疗前均有明显改善(P<0.05,<0.01);总有效率治疗组高于对照组;关节肿胀指数、关节压痛指数及血小板治疗前后差异治疗组高于对照组,差异均有统计学意义(P<0.05或P<0.01)。结论鹿瓜多肽注射液辅助治疗活动期类风湿性关节炎具有良好的效果。Objective To explore the clinical efficacy of Lugua polypeptide injection adjuvant therapy for rheumatoid arthritis in active stage. Methods 108 cases of rheumatoid arthritis patients were randomly divided into treatment group and control group. The patients in treatment group received conventional diclofenac sodium sustained-release tablets, supplemented by static drop treatment of Lugua polypeptide injection, the patients in control group received diclofenac sodium sustained-release tablets. The changes in clinical and laboratory parameters before and after treatment between two groups were observed. Results After three weeks of treat- ment, patients＂ morning stiffness time of two groups, joint swelling index, joint tenderness index and erythrocytes subsidence rate were improved obviously than that before the treatment （ P 〈 0.05, P 〈 0.01 ） ; the total effective rate were higher in treatment group than in control group; the changes of joint swelling index, joint tenderness index and antiplatelet therapy before and after treatment were more obvious in treatment group than in control group, the differences had statistical significance （ P 〈 0.05 or P 〈 0. 01 ）. Conclusion Lugua polypeptide injection adjuvant therapy has good effect in treating rheumatoid arthritis in active stage.

关 键 词：活动期类风湿关节炎 鹿瓜多肽 

分 类 号：R684.3[医药卫生—骨科学]