缺血修饰白蛋白在急性冠脉综合征早期诊断中的临床应用  

Clinical research of ischemia modified albumin in the early diagnosis of acute coronary syndrome

作　　者：陈阵[1] 李民[2] 高广卫[1] 谷晓建[1] 

机构地区：[1]大连医科大学附属第一医院检验科,辽宁大连116021 [2]解放军第210医院检验科,辽宁大连116021

出　　处：《临床军医杂志》2011年第6期1185-1186,共2页Clinical Journal of Medical Officers

摘　　要：目的探讨缺血修饰白蛋白(IMA)对急性冠脉综合征(ACS)的早期诊断价值。方法经确诊的ACS患者72例3 h内取血测定IMA、肌酸激酶(CK)、肌酸激酶同工酶质量(CK-MBmass)、肌钙蛋白I(cTnI)和肌红蛋白(MYO),观察其变化水平并作比较。同时取50例健康体检者抽血测定IMA作为对照组,观察其变化水平。结果观察组IMA水平明显高于对照组,ACS胸痛病人在胸痛发作就诊3h内抽血检测IMA阳性率达到77.8%,明显高于其他4种心肌标志物。结论 IMA可对急性心肌缺血做出早期诊断,在ACS的早期诊断与排除诊断中比其他4个标志物指标更为敏感。Objective To investigate the early diagnostic value of ischemia modified albumin （IMA） in acute coronary syndromes （ACS）. Methods The variation laws were observed by measuring IMA, creatine kinase （ CK）, CK-MBmass, myoglobin （MYO） and cTnI of 72 patients in 3 hours after confirmed diagnosis. And 50 healthy people were measured IMA and the other four myocardial markers as comparison at the same time, the changes were observed. Results The IMA values of the observation group were obviously higher than that of control group. When the myocardial ischemia took place in 3 hours in ACS patients, the positive rate of IMA was 77.8% and was obviously higher than other four cardio markers. Conclusion IMA can make the early diagnosis of acute myocardial ischemia; it is more sensitive in early diagnosis and diagnosis of exclusion than the other four markers.

关 键 词：急性冠脉综合征 缺血修饰白蛋白 

分 类 号：R542.2[医药卫生—心血管疾病]