着丝点蛋白B阳性19例临床分析  

Clinical analysis on 19 cases of centromere protein B positive patients

作　　者：于贤奎[1] 王化芬[1] 许会彬[1] 陈国敏[1] 田玉静[1] 

机构地区：[1]解放军第88医院检验科,山东泰安271000

出　　处：《临床军医杂志》2011年第6期1197-1198,共2页Clinical Journal of Medical Officers

摘　　要：目的探讨着丝点蛋白B检测的临床意义。方法选取19例单独着丝点蛋白B阳性患者的临床资料进行回顾性分析。结果 19例着丝点蛋白B阳性患者中类风湿关节炎(RA)5例(26.32%)、系统性红斑狼疮(SLE)3例(15.8%)、原发性胆汁性肝硬化(PBC)3例(15.8%)、干燥综合征(SS)3例(15.8%)、混合型结缔组织病(MCTD)2例(10.5%)、慢性淋巴细胞白血病1例(5.3%)、慢性肾功能不全1例(5.3%)、骨髓纤维化1例(5.3%)。结论着丝点蛋白B可出现在多种疾病中,以自身免疫性疾病为主,应当加强对着丝点蛋白B的认识,结合临床判断,防止误诊。Objective To investigate the significance of detection of centromere protein B in patients. Methods The clinical data of 19 patients with simple positive eentromere protein B were retrospective analyzed. Results In total 19 cases of simple centromere protein B positive patients, there were 5 patients with rheumatoid arthritis （ RA, 26.3% ）, 3 with systemic lupus erythematosus （SLE, 15.8% ）, 3 with primary biliary cirrhosis （PBC, 15.8% ）, 3 with sjogren＇ s syndrome （SS, 15.8% ）, 2 with mixed connective tissue disease （ MCTD, 10.5 % ）, 1 with chronic lymphoblastic leukemia （5.3%）, 1 with chronic renal insufficiency （5.3%）, 1 with myelofibrosis （5.3%）. Conclusion Many diseases can induce positive centromere protein B, they were autoimmune diseases mainly. We should strengthen the understanding of the centromere protein B, combined with clinical judgement to prevent misdiagnosis.

关 键 词：着丝点蛋白B 抗着丝点抗体 类风湿关节炎 

分 类 号：R446.42[医药卫生—诊断学]