蓝藻为载体的阿维菌素抗紫外缓释剂的制备及其性能  

Preparation of Anti-UV Controlled Release Formulation of Avermectin with Carrier of Blue Algae and Its Property

作　　者：侯宏伟[1] 任天瑞[1] 燕云峰[1] 王全喜[1] 徐文平[2] 

机构地区：[1]上海师范大学生命与环境科学学院,上海200234 [2]华东理工大学药学院,上海200237

出　　处：《过程工程学报》2011年第5期846-850,共5页The Chinese Journal of Process Engineering

基　　金：国家自然科学基金资助项目(编号:20872093);国家高技术研究发展计划(863)基金资助项目(编号:2011AA100503);国家十二五科技支撑计划基金资助项目(编号:2011BAE06B06);上海市教委资助项目(编号:11ZZ122);上海市重点学科基金资助项目(编号:S30406)

摘　　要：以滇池蓝藻为载体,利用其抗紫外特性,用卡波姆树脂包裹蓝藻?阿维菌素(Avermectin,Av)粉,制成阿维菌素抗紫外缓释剂,利用FT-IR,SEM和HPLC等对蓝藻和缓释剂进行表征,研究其吸附与释放行为.结果表明,Av在异丙醇中的饱和吸附量为160.81mg/g,包裹10%卡波姆树脂的抗紫外缓释剂具有很好的缓释功能,在乙醇/水(4:1,φ)中释放20d,累计释放率为51.8%,释放机制是Fick扩散和骨架溶蚀的双重机制.经4h紫外光照射,含蓝藻的制剂中Av残留量为61%,不含蓝藻的制剂中Av残留量为39%.A major objective of the present work is to develop anti-UV controlled release formulation of avermectin（Av）,with utilizing the anti-UV characteristic of blue algae as carrier taken from Dianchi Lake.Av was adsorbed on blue algae powder and then coated with 10% carbomer resin.The blue algae powder and release formulation were characterized by FT-IR,SEM and HPLC.The results show that the adsorptive capacity of Av is 160.81 mg/g in isopropanol at 25℃.The formulation release rate is 51.8% for 20 d in ethanol/water（4：1,j） at 25℃.The controlled release mechanism belongs to Fickian diffusion and matrix erosion.The residual rates of Av with blue algae and alone are 61.0% and 39.0% respectively under UV irradiating.It is improved that blue algae has the function of resistance against UV.

关 键 词：蓝藻 阿维菌素 抗紫外缓释剂 

分 类 号：O632.5[理学—高分子化学] TQ314.255[理学—化学]