Radiation-induced robust oscillation and non-Gaussian fluctuation  

作　　者：刘波 晏世伟 耿轶钊 

机构地区：[1]Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,Institute of High Energy Physics,Chinese Academy of Sciences [2]Key Laboratory of Beam Technology and Material Modification of Ministry of Education,Beijing Normal University [3]College of Nuclear Science and Technology,Beijing Normal University [4]Beijing Radiation Centre [5]Centre of Theoretical Physics,National Laboratory of Heavy Ion Accelerator of Lanzhou

出　　处：《Chinese Physics B》2011年第12期465-468,共4页中国物理B（英文版）

基　　金：Project supported by the National Natural Science Foundation of China (Grant No. 10975019);the Scientific Research Foundation for the Returned Overseas Chinese Scholars,Ministry of Personnel of China (Grant No. MOP2006138);the Fundamental Research Funds for the Central Universities;the Science Foundation of the Ministry of Science and Technology of China (Grant No. 2012CB934001)

摘　　要：There have been many recent studies devoted to the consequences of stochasticity in protein circuitry. Stress conditions, including DNA damage, hypoxia, heat shock, nutrient deprivation, and oncogene activation, can result in the activation and accumulation of p53. Several experimental studies show that oscillations can be induced by DNA damage following nuclear irradiation. To explore the underlying dynamical features and the role of stochasticity, we discuss the oscillatory dynamics in the well-studied regulatory network motif. The fluctuations around the fixed point of a delayed system are Gaussian in the limit of sufficiently weak delayed feedback, and remain Gaussian along a limit cycle when viewed tangential to the trajectory. The experimental results are recapitulated in this study. We illustrate several features of the p53 activities, which are robust when the parameters change. Furthermore, the distribution in protein abundance can be characterized by its non-Gaussian nature.There have been many recent studies devoted to the consequences of stochasticity in protein circuitry. Stress conditions, including DNA damage, hypoxia, heat shock, nutrient deprivation, and oncogene activation, can result in the activation and accumulation of p53. Several experimental studies show that oscillations can be induced by DNA damage following nuclear irradiation. To explore the underlying dynamical features and the role of stochasticity, we discuss the oscillatory dynamics in the well-studied regulatory network motif. The fluctuations around the fixed point of a delayed system are Gaussian in the limit of sufficiently weak delayed feedback, and remain Gaussian along a limit cycle when viewed tangential to the trajectory. The experimental results are recapitulated in this study. We illustrate several features of the p53 activities, which are robust when the parameters change. Furthermore, the distribution in protein abundance can be characterized by its non-Gaussian nature.

关 键 词：nuclear radiation DNA damage non-Gaussian activity ROBUSTNESS 

分 类 号：Q26[生物学—细胞生物学]