六味补血颗粒的喷雾制粒工艺研究  

Spraying granulation technique of Liuwei Buxue Keli

作　　者：李剑欣[1] 张曦[1] 魏桂蓉 

机构地区：[1]湖南省娄底市中心医院药剂科,湖南娄底417000

出　　处：《中南药学》2011年第11期841-844,共4页Central South Pharmacy

摘　　要：目的优化六味补血颗粒的喷雾制粒工艺。方法 应用正交试验法,采用喷雾干燥制粒机制粒并在流化床上进行干燥,以浸膏浓缩的相对密度、物料干燥温度及雾化压力为考察因素,以颗粒成品收得率及芍药苷转移率为评价指标。结果最佳工艺参数:浸膏相对密度为1.10(80℃),物料干燥温度为95～100℃,雾化压力为0.25MPa。结论该工艺合理、稳定,为工业化生产提供了实验依据。Objective To optimize the condition of the spray granlulation of Liuwei Buxue Keli. Methods The process was studied by orthogonal experimental design, newly-fluid-bed-spray-deier-granulation technique was adopted, and relative density of the fluid extracts, drying temperature and spray pressure were used as inspecting factors, end-product and the transferring rate of paeoniflorin were used as inspecting markers. Results The optimum spraying granulation technique of Liuwei Buxue Keli was as follows： the relative density of the fluid extracts was 1.10 （80 ℃）, the drying temperature was 95-100 ℃ and the spray pressure was 0. 25 MPa. Conclusion The process is rational and stable, which can provide the experimental basis for industrial production.

关 键 词：六味补血颗粒 喷雾制粒 正交试验 

分 类 号：R944.2[医药卫生—药剂学]