氧化低密度脂蛋白自身抗体与动脉粥样硬化关系的研究  

Study on the relationship between autoantibodies against oxidized low density lipoprotein and artherosclerosis

作　　者：赵炜[1] 刘小玲[2] 田刚[3] 

机构地区：[1]新疆维吾尔自治区阿克苏地区第一人民医院检验科,843000 [2]新疆维吾尔自治区喀什地区第一人民医院内科干部病房,844000 [3]天津公安医院检验科,300040

出　　处：《检验医学与临床》2011年第24期2994-2994,2996,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨氧化低密度脂蛋白自身抗体(OX-LDL-Ab)在动脉粥样硬化(AS)发生、发展中的作用及其关系。方法应用酶联免疫吸附试验对50例健康对照组及60例AS组患者血清中抗氧化低密度脂蛋白免疫复合物中OX-LDL-Ab进行测定。结果健康对照组与AS组OX-LDL-Ab阳性率分别为0和91.67%,OX-LDL-Ab水平分别为(88.2±5.1)U/L和(285.2±5.5)U/L,两组比较差异均有统计学意义(P<0.01)。结论 OX-LDL-Ab可作为早期诊断AS发生的一个可靠指标。Objective To investigate the relationship between autoantibodies against oxidative low density lipoprotein（OX-LDL-Ab） and artherosclerosis（AS）. Methods The OX LDL Ab in immunocomplex of 60 patients with suspected AS and 50 healthy control group were determined by ELISA assay. Results The positive rates of OX LDL-Ab of the control group and AS group were 0 and 91. 67% ,respectively. The levels of OX-LDL-Ab in the two groups were（88.2±5.1）U/L and （285.2±5.5）U/L,respectively. The difference between the two groups was sig nificant（P〈0.01）. Conclusion Detection of OX-LDL-Ab can be applied in the early diagnosis of AS.

关 键 词：氧化低密度脂蛋白自身抗体 酶联免疫吸附试验 动脉粥样硬化 

分 类 号：R514.4[医药卫生—内科学]