支链氨基酸作为药理营养素在慢性肝病治疗中的应用  

Branched-Chain Amino Acids as Pharmacological Nutrients in Chronic Liver Disease

作　　者：王芃[1] 谢青[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院感染科,上海200025

出　　处：《药学与临床研究》2011年第6期481-484,共4页Pharmaceutical and Clinical Research

基　　金：国家科技部十一五重大传染病专项(2008ZX10002-005;2008ZX10002-007)

摘　　要：支链氨基酸是一组包括缬氨酸、亮氨酸和异亮氨酸等的人体必需氨基酸。支链氨基酸除了其蛋白质成分的作用,可能对慢性肝病患者具有药理营养素作用。本文从基础研究和临床角度对支链氨基酸在合成白蛋白和胰岛素抵抗作用上可能产生的影响,以及对肝癌和肝硬化患者的生活质量和预后的临床作用作一综述。Branched-chain amino acids（BCAAs） are a group of essential amino acids including valine,leucine and isoleucine.A low ratio of plasma BCAAs to aromatic amino acids is a physiological hallmark of liver cirrhosis.Recent studies on BCAAs have revealed that,in addition to their role as protein constituents,they may have a role as pharmacological nutrients for patients with chronic liver disease.This review summarizes the possible effects of BCAAs on albumin synthesis and insulin resistance from clinical and basic viewpoints.Meanwhile,the newly discovered clinical impact of BCAAs on the prognosis and quality of life of patients with hepatocellular carcinoma and liver cirrhosis are reviewed.

关 键 词：支链氨基酸 慢性肝病 胰岛素抵抗 肝癌 临床失代偿 

分 类 号：R977.4[医药卫生—药品] R975.5[医药卫生—药学]