七叶皂苷钠联合半量甘露醇不同应用顺序对治疗小腿创伤性水肿的疗效比较  

Effect Comparison between Different Application Sequences of the Union Medication of Sodium Aescinate and Half-dose Mannitol for Traumatic Shank Edema

作　　者：覃柏[1] 万磊[2] 沈洪园[2] 林淮[2] 

机构地区：[1]广州军区广州总医院药剂科,广州510515 [2]广州军区广州总医院骨科,广州510515

出　　处：《药学与临床研究》2011年第6期542-544,共3页Pharmaceutical and Clinical Research

摘　　要：目的:研究七叶皂苷钠联合半量甘露醇治疗小腿创伤性水肿的用药方式,为临床合理用药提供参考。方法:134例闭合性胫腓骨骨折合并小腿软组织肿胀患者随机分为A、B组,每组67名患者,A组用七叶皂苷钠后接半量甘露醇静滴,B组半量甘露醇后接七叶皂苷钠静滴。治疗3天后观察疗效以及并发症。结果:A组显效率为56.72%,总有效率为95.52%;B组显效率为35.82%,总有效率为86.57%;两组病人治疗效果有显著差异(χ2=7.228,P<0.05)。A组静脉炎发生率为20.90%;B组静脉炎静脉炎发生率为53.73%;两组病人静脉炎发生率有显著差异(χ2=18.359,P<0.01)。结论:用七叶皂苷钠后接半量甘露醇静滴是较好的联合用药方式,可提高消除水肿效果,减少静脉炎并发症。Objective： To provide a reasonable reference for clinical medication,the union medication of sodium aescinate and half dose mannitol for traumatic shank edema were studied.Methods： The 134 cases of closed fracture of tibiofibula with concurrent shank soft tissue swelling were divided randomly into group A or B.Group A used sodium aescinate first,and then half dose mannitol intravenous drip.Group B used half dose mannitol first,and then sodium aescinate intravenous drip.Their curative effects and complications were observed after three days＇ treatment.Results： The curative effective rate for Group A was 56.72%,significantly higher than that（35.82%） of Group B（P0.05）.The incidence of phlebitis for Group A was 21.90%,significantly lower than that of（53.71%） Group B（P0.05）.Conclusion： Sodium aescinate first,and then half-dose mannitol intravenous drip,is a better union medication.It can improve the effect of detumescence and reduce the complication of phlebitis.

关 键 词：七叶皂苷钠 半量甘露醇 创伤性水肿 

分 类 号：R969.4[医药卫生—药理学]