流动注射化学发光法测定盐酸麻黄碱  

Determination of ephedrine hydrochloride by flow injection analysis with chemiluminescence detection

作　　者：吴丽红[1] 王娜[1] 卜敏[1] 聂菲[1] 

机构地区：[1]西北大学分析科学研究所,西安710069

出　　处：《药物分析杂志》2011年第12期2322-2324,共3页Chinese Journal of Pharmaceutical Analysis

基　　金：陕西省教育厅项目(09JK764)资助

摘　　要：目的:建立灵敏的流动注射化学发光分析测定盐酸麻黄碱的方法。方法:基于盐酸麻黄碱在酸性条件下对Ce(Ⅳ)-Na2 SO3化学发光反应的增敏作用,建立了流动注射化学发光测定盐酸麻黄碱的新方法。结果:在优化的条件下,测定盐酸麻黄碱的线性范围为8.0×10-8～2.0×10-6 g.mL-1(r=0.9941),检出限为2×10-8 g.mL-1。结论:该方法简便,且有较高的灵敏度和准确度,对麻黄碱药物分析以及毒品检测都有重要的意义。Objective：To establish a sensitive flow injection-chemiluminescence（CL） method for the determination of ephedrine hydrochloride.Method：Based on the sensitization of ephedrine hydrochloride on the Ce（Ⅳ）-Na2SO3CL reaction in acidic conditions,a novel flow injection CL method for the determination of ephedrine hydrochloride was established.Results：Under the optimized conditions,the linear response range for the determination of hydrochloride was from 8.0×10-8 to 2.0×10-6 g·mL-1 with a linear correlation coefficient of 0.9941.The detection limit was 2×10-8 g·mL-1.Conclusion：The proposed method is simple,sensitive and accurate.It is of great significance for ephedrine in pharmaceutical analysis and toxicological analysis.

关 键 词：盐酸麻黄碱 铈-亚硫酸钠 化学发光 流动注射分析 毒品检测 兴奋剂检测 

分 类 号：R917[医药卫生—药物分析学]