高龄老年人群动脉弹性的影响因素  

Arterial Elasticity in Elder Patients With its Influencing Factors

作　　者：宝辉[1] 苗懿德[1] 孙宁玲[2] 李卫[1] 刘杰[1] 郏蓉[1] 魏雅楠[1] 褚琳[1] 刘颖[1] 卢熙宁[2] 

机构地区：[1]北京大学人民医院老年科,北京市100044 [2]北京大学人民医院心脏中心高血压科,北京市100044

出　　处：《中国循环杂志》2011年第6期450-453,共4页Chinese Circulation Journal

摘　　要：目的:探讨高龄老年人群动脉弹性的影响因素。方法:选取高血压病高龄老年患者260例,分为单纯高血压组127例、高血压合并糖尿病组133例,并设同期查体或其他原因住院、不伴高血压及糖尿病的54例高龄老人为正常血压组,测定其身高、体重、血压及生化指标,用自动分析仪检测大动脉弹性指数(C1)和小动脉弹性指数(C2)。比较患者合并不同疾病时动脉弹性情况,对C1、C2进行相关及回归分析。结果:①同正常血压组相比,单纯高血压组的收缩压升高,C1和C2降低(P<0.05),高血压合并糖尿病组的体重指数、甘油三酯、空腹血糖、尿酸、收缩压升高,C1和C2降低(P<0.05);同单纯高血压组相比,高血压合并糖尿病组的体重指数、空腹血糖、尿酸升高,C2降低(P<0.05),而C1的差异无统计学意义(P=0.704)。②多元线性逐步回归分析显示,高龄老年患者的C1与年龄、收缩压、胆固醇负相关(R^2=0.507,P<0.05);C2与收缩压、年龄、低密度脂蛋白胆固醇、有无糖尿病负相关(R^2=0.464,P<0.05)。结论:年龄和收缩压与高龄老年患者动脉弹性密切关联,另外C1与胆固醇负相关,C2与低密度脂蛋白胆固醇及有无糖尿病负相关。Objective：To explore the arterial elasticity in elder patients with its influencing factors. Methods ： A total of 260 elder patients at 80 - 96 years of age who suffered from essential hypertension were divided into two groups ： Semplice hypertension group, n= 127 and Hypertension combined with diabetes group, n = 133. There were 54 subjects with the matched age without hypertension nor diabetes served as Control group. The body mass index （BMI） , height, blood pressure and biochemical indicators were examined in each participant. The large artery elasticity （ C1 ） and small artery elasticity （C2） were measured and compared among different groups. The risk factors between arterial elasticity and different diseases were studied by multiple linear regression analysis. Results：（1）Compared with Control group, in Semplice hypertension group, the patients presented higher systolic blood pressure, lower C1 and C2, P〈0.05 respectively; in Hypertension combined with diabetes group, the patients had higher BMI, higher triglyceride, fasting blood sugar, uric acid and systolic blood pressure, had lower C1 and C2, P〈0. 05 respectively. Compared with Semplice hypertension group, the patients in Hypertension combined with diabetes group had higher BMI, higher fasting blood sugar, uric acid and lower C2, P〈0. 05 respectively, CI was similar between two groups, P=0. 704. （2） Multiple linear re- gression analysis indicated that C1 was negatively related to the age, systolic blood pressure and cholesterol （R2 = 0. 507, P〈 0. 05 ）, C2 was negatively related to systolic blood pressure, age, LDL-C and diabetes （R2 =0. 464 ,P〈0. 05 ）. Conclusion ： Arterial elasticity are closely related to the age and systolic blood pressure in elder patients, clis negatively relat- ed to cholesterol, C2 negatively related to LDL-C and diabetes.

关 键 词：高龄老年 大动脉弹性指数 小动脉弹性指数 危险因素 

分 类 号：R541[医药卫生—心血管疾病]