真武汤对肾阳虚肾衰模型大鼠肾脏病理影响  

Effect of Zhenwu Tang on kidney pathology of renal failure with kidney-yang deficiency syndrome in rats

作　　者：宋伟[1] 李明哲[2] 关佳楠[3] 刘芳[1] 乔春红[2] 赵甲秀[2] 

机构地区：[1]辽宁中医药大学,沈阳110032 [2]辽宁中医药大学附属第三医院,沈阳110003 [3]沈阳市第五人民医院,沈阳110023

出　　处：《中国中医基础医学杂志》2011年第12期1336-1337,共2页JOURNAL OF BASIC CHINESE MEDICINE

摘　　要：目的:本研究以形态学等检测技术,观察真武汤对肾阳虚型慢性肾衰模型大鼠肾组织的影响。方法:通过研究温补肾阳传统名方真武汤对肾阳虚慢性肾衰模型肾脏病理的影响,观察真武汤对肾功能的保护作用。结果:与对照组比较,模型组大鼠肾组织光镜观察可见肾小球充血、囊腔扩大、间质纤维组织增生及大量炎细胞浸润,肾小管呈代偿性扩张。真武汤组大鼠肾组织光镜观察可见病理损伤明显减轻。结论:肾阳虚型慢性肾衰模型大鼠肾组织病理可见明显损伤,真武汤能够使其逆转。Purpose：In this study,we set up rats the model of chronic renal failure with kidney-yang deficiency,by using biology and morphology technique.Methods：Thirty Healthy male wistar rats were randomized into normal group,model group and zhenwu decotion group.Drawing materials from rats and indexes were detected.Results：Impact of zhenwu decotion on renal function of chronic renal failure rats with kidney-yang deficiency.Renal tissue by light microscopy observation shows glomerular hyperemia,expand cysts,interstitial fibrosis and a large amount of inflammatory cell infiltration,tubular compensatory enlargement.Compared with model group,zhenwu decotion group rats renal tissue pathological injury relieved.The theory of Chinese medical considered kidney governing water.It mainly manifested in maintaining the balance of the body water metabolism.During kidney yang deficiency,it will occur obstruction of qi activities and result in disturbance of water metabolism.Conclusions：Chronic renal failure rats with kidney-yang deficiency have a marked decreased renal tissue pathological injury significantly.After treatment zhenwu decotion can reverse this process.

关 键 词：慢性肾功能衰竭 肾阳虚 真武汤 

分 类 号：R285.6[医药卫生—中药学]