VIM型金属β-内酰胺酶及抑制剂研究进展  

Recent Advances in Research of VIM Metallo-β-Lactamase and its Inhibitors

作　　者：房咪[1] 陈姣[1] 陈辉[1] 郑珩[1] 

机构地区：[1]中国药科大学生命科学与技术学院,南京210009

出　　处：《抗感染药学》2011年第4期221-226,共6页Anti-infection Pharmacy

基　　金：江苏省研究生创新工程项目(CXZZ11_0826);教育部中央高校基本科研业务费专项基金(JKZ2009007和JKY2009054)

摘　　要：VIM金属β-内酰胺酶是1种能水解几乎所有(除氨曲南等单环外)的β-内酰胺类抗生素,也是已报道蛋白质中与新德里金属β-内酰胺酶(NDM-1)序列相似性最高的一类获得性金属β-内酰胺酶。VIM-1与NDM-1相似,前者基因易于在细菌间传播和扩散,迄今还未发现临床有效的抑制剂,所以研发新型有效的抑制剂迫在眉睫。综述了近年来VIM序列、结构特点、耐药机制及相关抑制剂的最新研究进展,为设计、筛选、开发新型VIM-1抑制剂奠定基础,亦可为深入了解NDM-1设计开发其抑制剂提供帮助。VIM metallo-β-lactamase was one of the acquired metaUo-β-lactamases that could hydrolyse almost all the β-lactam antibiotics except for monobactatam and have the highest sequence similarity to NDM-1 among proteins that had been reported. The gene of VIM-1 could spread among different bacteria, as same as NDM-1. Clinical treatment is encountering a great threat because of lacking effective inhibitors so far and is urgently requiring the VIM metallo-β-lactamase inhibitors. The sequences, characteristics of 3D-structures, resistance mechanisms and related inhibitors of VIM were summarized in order to lay the foundation for the design and screening of new types of inhibitors and to provide a guideline for the further understanding and development of inhibitors for NDM-1 metallo-β-lactamase.

关 键 词：VIM 金属Β-内酰胺酶 抑制剂 

分 类 号：R978.11[医药卫生—药品]