Graves病^(131)Ⅰ首次治疗的疗效与甲状腺大小相关性分析  

Correlation analysis between the thyroid size and therapeutic effect after initial dose of ^(131)Ⅰ for Graves′disease

作　　者：黄智慧[1] 谢彦[1] 罗芙蓉[1] 徐泉凤[1] 葛俊亮[1] 程光华[1] 

机构地区：[1]皖南医学院附属弋矶山医院核医学科,安徽芜湖241001

出　　处：《皖南医学院学报》2011年第6期461-463,共3页Journal of Wannan Medical College

摘　　要：目的:探讨治疗前甲状腺大小对131I首次治疗Graves病疗效的影响。方法:选择我科2007年1月～2009年8月第1次行131I治疗的Graves病患者,按甲状腺大小分为4组:正常大小组(10～25 g)、轻度肿大组(25～40 g)、中度肿大组(40～60 g),重度肿大组(60～90 g),并行疗效分析。结果:甲状腺正常组,轻、中、重度肿大组的治愈率、早发甲减发生率及晚发甲减发生率分别为:77.8%vs 68.9%vs65.1%vs 42.5%,47.2%vs 39.8%vs 36.3%vs 30.0%,41.7%vs 34.0%vs 28.8%vs 25.0%,4组组间治愈率及晚发甲减发生率差异均有显著意义(P<0.05),而早发甲减发生率差异无显著意义(P>0.05)。结论:甲状腺大小是影响131I治疗甲亢疗效的因素之一,甲状腺大小对131I首次治疗Graves病后致晚发甲减有影响,但对早发甲减的发生无明确影响。Objective：To investigate the thyroid weight responding to iodine-131 by initial dose administered to patients with Graves′ disease.Methods：The patients with Graves′ disease received initial dose of radioiodine therapy between Jan.2007 and Aug.2009 were allocated to four groups according to the thyroid size,i.e.,normal size（10-25 g）,mild thyromegaly（25-40）,moderate goiter（40-60） and severely enlarged thyroid（60-90）,for analysis of the therapeutic effect.Results：The recovery rates and incidences of both primary and permanent hypothyroidism in the four groups were 77.8% vs 68.9% vs 65.1% vs 42.5%,47.2% vs 39.8% vs 36.3%vs 30.0%,41.7% vs 34.0% vs 28.8% vs 25.0%,respectively,which was significantly different regarding the curative rate and incidence of permanent hypothyroidism（P0.05）,yet suggested no difference in primary hypothyroidism（P0.05）.Conclusion：The thyroid weight is one of the influential factors with the therapeutic outcomes by iodine-131.Additionally,the size of thyroid may be associated with the permanent hypothyroidism but not with primary hypothyroidism responding to initial dose of radioiodine in patients with Graves′ disease.

关 键 词：GRAVES病 ~131Ⅰ 甲状腺大小 首次治疗 

分 类 号：R581.1[医药卫生—内分泌]