新疆乌鲁木齐地区人群碘摄人量与甲状腺疾病的相关研究  

Relationship between iodine intake and the prevalence of thyroid disease in Urumqi, Xinjiang

作　　者：张明琛[1] 张丽[1] 樊勇[1] 曾小云[1] 朱筠[1] 阿不力克木[1] 伊力多斯[1] 

机构地区：[1]新疆医科大学第一附属医院内分泌科,乌鲁木齐830054

出　　处：《中华内分泌代谢杂志》2011年第12期972-974,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：新疆维吾尔自治区自然科学基金项目（2009211A20）

摘　　要：目的 了解乌鲁木齐地区人群目前碘营养状况、甲状腺疾病流行情况并探讨两者的关系.方法 对新疆乌鲁木齐地区1693名成人进行体格检查、问卷调查,并测定平均尿碘中位数、甲状腺功能、甲状腺相关抗体和进行甲状腺B超检查.结果 在调查人群中,碘缺乏人数仅占9.5％,而碘过量人数达到30.0％.平均尿碘中位数达254.9 μg/L.碘充足/超足量组TT4水平明显高于其他两组[（9.02±2.63）对（7.69±2.85）、（8.45±2.13）μg/dl,均P＜0.05],碘缺乏组TSH水平显著高于其他两组[（3.00±1.86）对（2.37±1.91）、（2.27±1.86） mIU/L,均P＜0.01].各组甲状腺球蛋白抗体、甲状腺过氧化物酶抗体阳性率及甲状腺功能异常、甲状腺结节患病率没有统计学差别.结论 目前新疆乌鲁木齐地区碘缺乏状态已纠正,平均尿碘中位数254.9 μg/L.不同碘摄入状态人群甲状腺疾病患病率无统计学差别.Objective To evaluate the relationship between iodine intake and the prevalence of thyroid diseases in Urumqi.Methods A total of 1693 subjects were investigated.Serum thyroid hormones,thyroid autoantibodies,and urinary iodine concentration were determined,and type B ultrasonography of thyroid gland was performed in all participants.Result The urinary iodine level revealed that 9.5% of the subjects were iodine deficient and 30.0% iodine excessive.The average median urinary iodine was 254.9 μg/L.Serum total T4 level in the idione adequate and more than adequate groups was significantly higher than the other 2 groups [ （ 9.02±2.63 ） vs （7.69±2.85）、（8.45 ±2.13 ） μg/dl,both P〈0.05 ],and serum TSH level in the idione deficient group was significantly higher than the other 2 groups [ （3.00±1.86） vs （2.37±1.91）,（2.27±1.86） mIU/L,both P〈0.01 ].There was no significant statistical difference in positive rates of thyroid autoantibodies,morbidities of thyroid dysfunction and goiter among 3 groups.Conclusion The iodine deficient situation has been corrected in Urumqi.There is no difference in morbidities of thyroid diseases in population with different iodine intakes.

关 键 词：碘 甲状腺功能 甲状腺结节 

分 类 号：R581[医药卫生—内分泌]