小牛血去蛋白提取物眼用凝胶治疗LASIK术后并发干眼症研究  

The study on the treatment effect of protein-free calf blood extract gel in dry eyes after LASIK

作　　者：邹广程[1] 华芳芳[1] 叶静娟[1] 武志峰[1] 

机构地区：[1]无锡市第二人民医院,无锡214000

出　　处：《中国实用眼科杂志》2011年第12期1258-1260,共3页Chinese Journal of Practical Ophthalmology

摘　　要：目的 评价小牛血去蛋白提取物眼用凝胶治疗LASIK术后干眼症的临床治疗效果。方法取2008年1月至2009年12月间在行LASIK手术后发生干眼症的单纯近视及近视散光患者76例（152只眼），采用自身对照法，每例随机选取一只眼进入治疗组（小牛血去蛋白提取物眼用凝胶滴眼）；另一只眼进入对照组（0．1％玻璃酸钠滴眼液滴眼）。术后1d、1周、1月、3月观察眼部不适主诉、ShirmerI试验、BUT、荧光素染色结果。结果眼部不适主诉术后1周、1月实验组明显低于对照组（P〈0．05）；ShirmerI试验术后1周、1月实验组明显长于对照组（P〈0．05）；BUT术后1周、1月、3月实验组明显长于对照组（P〈0．05）；荧光素染色分级术后1d和1月实验组明显低于对照组（P〈0．05）。结论小牛血去蛋白提取物眼用凝胶治疗LASIK术后干眼症疗效确切、起效时间短、能够有效改善患者不适症状及体征。Objective To evaluate the treatment effect of expression of protein-free calf blood extract gel in dry eyes after LASIK. Methods A total of 76 cases （152 eyes） of dry eye after LASIK were collected for study. Each case was chosen one eye into experiment group （treated with protein-free calf blood extract gel） and the other eye into control group （treated by 0.1% sodium hyaluronate drop） at random. The discomfortness of eyes, Shirmer I test, tear breaking-up time （BUT） and fluorescent bangle staining of cornea were tested and marked after 1 day, 1 week, 1 month and 3 months after LASIK. Results Between experiment group and control group, the discomfortness of eyes were significant less in experiment group at 1 week and 1 month after LASIK （P 〈0.05）; the Shirmer I test wetting were significant length at 1 week and 1 month after LASIK （P 〈0.05）; the BUT were significant longer at 1 week, 1 month and 3 months after LASIK （P 〈0.05）; the level of fluorescent bangle staining of cornea were significant reduced at 1 day and 1 month after LASIK （P 〈0.05）. Conclusions Protein-free calf blood extract gel can be used to improve on the symptom,objective sign in dry eyes after LASIK.

关 键 词：干眼症 小牛血去蛋白提取物 LASIK 治疗 

分 类 号：R975[医药卫生—药品]