血余炭止血包止血效果的实验研究  

Experimental study on hemostasis effect of carbonized hair

作　　者：朱元元[1] 邱彦[1] 鲁毅[1] 刘梅[1] 刘静[1] 

机构地区：[1]解放军第454医院,江苏南京210002

出　　处：《药学实践杂志》2011年第6期431-434,共4页Journal of Pharmaceutical Practice

基　　金：南京军区医学科研基金(09Z014)

摘　　要：目的观察血余炭止血包的止血作用。方法以兔子为实验对象,采用试管法测定体外凝血时间;用巴马小型猪建立其肝脏、脾脏、股动、静脉创伤出血模型,观察血余炭止血包的止血效果。结果体外凝血实验,与云南白药组、空白对照组和阴性对照淀粉组比较,血余炭组体外凝血时间明显缩短(P<0.05,P<0.01)。在巴马小型猪创伤止血实验中,与阴性对照淀粉组比较,血余炭止血包能明显缩短巴马小型猪肝脏、脾脏创伤出血时间(P<0,01),并明显减少出血量(P<0,01)。与云南白药组和阴性对照淀粉组比较,血余炭组对巴马小型猪股动、静脉创伤出血有显著性止血作用(P<0,05,P<0.01)。组织学观察,股动脉创面组织周围未见明显病理改变。结论血余炭止血包有较好的凝血效果,在巴马小型猪肝脏、脾脏创伤出血模型中能明显缩短出血时间,减少出血量,止血实验效果显著;能有效控制模型中股动、静脉致命性出血,降低死亡率。Objective To observe the hemostasis effect of carbonized hair. Methods The coagulation time was measured in vitro with blood collected from rabbits in the presence of blank, starch, carbonized hair or Yunnan White Drug-Powder respectively. Bama miniature pigs traumatic model was established and animal haemostatic experiment was performed. Hemostatic effect was observed in liver, spleen and femoral arteriovenous fistula hemorrhagic model of Bama miniature pigs. Results The coagulation time of rabbit blood was markedly shorter by addition of carbonized hair compared to Yunnan White Drug-Powder, starch and blank （P 〈 0. 05 ,P 〈 0.01 ）. Compare with the starch group, carbonized hair could significantly shorten the bleeding time and decrease the volume of bleed- ing （P 〈 0.01 ） , in the liver and spleen of hemorrhagic model of Bama miniature pigs. Compared with the Yunnan White Drug-Powder and the starch, carbonized hair could more effectively stop the femoral arteriovenous fistula bleeding in the model of Bama miniature pigs （P 〈0. 05 ,P 〈0.01 ）. Histologic study revealed there was no significant pathological change around the femoral artery. Conclu- tion Carbonized hair could effectively inhibit blood coagulation in vitro, decrease bleeding volume and bleeding time in the liver and spleen of hemorrhagic model of Bama miniature pigs. Carbonized hair dressing could also effectively control hemorrhage in femoral arte- riovenous fistula model with lethal vascular injury.

关 键 词：血余炭 止血 出血 动脉 创伤 

分 类 号：R973.1[医药卫生—药品]