钩藤总碱的热稳定性研究  

Studies on thermal stability of total alkaloids in rhynchophylline

作　　者：刘卫[1] 杨雪萍[1] 王中师[1,2] 王盟[1] 张强[1] 郝立勇[2] 

机构地区：[1]解放军第88医院药剂科,山东泰安271000 [2]泰山医学院药学院,山东泰安271000

出　　处：《药学实践杂志》2011年第6期442-444,共3页Journal of Pharmaceutical Practice

基　　金：山东省科技发展计划项目(2008GG2NS02006)

摘　　要：目的考察钩藤总碱的热稳定性。方法在不同温度条件下,用高效液相色谱检查钩藤总碱中的钩藤碱和异钩藤碱。结果与钩藤碱相比,异钩藤碱溶液对热不稳定,60℃或90℃2 h后异钩藤碱含量明显降低,而钩藤碱溶液在60℃2 h或4℃6 d的环境中稳定。而且,钩藤碱和异钩藤碱成盐后更加稳定。结论异钩藤碱的热不稳定性是钩藤"后下"的原因。Objective To investigate the effect of heating on total alkaloids in rhynchphylla. Methods HPLC was employed to determine rhynehophylline anti isorhynehophylline in total alkaloids among various conditions. Results Comparing with rhyneho- phylline, isorhynchophylline was unstable to heating. Heated in 60℃ and 90 ℃for 2 hours, isorhynehophylline content decreased more than 38% and 50% , respectively. But rhynchophylline solution was stable in 60 ~C for 2 hours and 4 ~C for 6 days. In addition, rhynthophylline and isorhynehophylline were more stable in salt formation. Conclusion Isorhynehophy/line was unstable to heating, whieh was the reason for rhynchophylla to given later, in decoct herbal medicine.

关 键 词：钩藤碱 异钩藤碱 钩藤总碱 

分 类 号：R931.6[医药卫生—生药学]