胰腺癌中MMP-9和E-cad的表达及意义  

Expression and clinical significance of matrix met alloproteinase-9 and E-cadherin in pancreatic cancer

作　　者：黄项武[1,2] 程志清[1,2] 林芳英[1,2] 陈建阳[1,2] 蔡静瑜[1,2] 蔡清河[1,2] 陈金坤[1,2] 

机构地区：[1]福建省莆田学院附属医院普外科 [2]福建省莆田学院附属医院病理科,351100

出　　处：《中国实用医药》2011年第32期28-30,共3页China Practical Medicine

摘　　要：目的研究MMP-9和E-cad在胰腺癌组织中的表达,并探讨它们的相关性及临床意义。方法采用免疫组化SP法检测15例正常胰腺组织、30例胰岛素细胞瘤和50例胰腺癌组织中MMP-9和E-cad的表达情况。结果 MMP-9和E-cad在胰腺癌组织中的阳性表达率分别为82%、24%;MMP-9为高表达,E-cad为低表达,MMP-9和E-cad蛋白的表达与有无淋巴结转移和分化程度相关(P<0.05);两种蛋白在胰腺癌组织中的表达呈负相关(P<0.05)。结论 MMP-9和E-cad在肿瘤侵袭转移中发挥了重要作用,检测MMP-9和E-cad的表达可作为预测胰腺癌的转移趋势指标,并能有效的评估胰腺癌患者的预后。Objective To observe the expression and of matrix met alloproteinase 9 protein（MMP-9） and E-cadherin protein（E-cad） in pancreatic cancer,and to investigate the correlation and clinical significance of MMP-9 and E-cad proteins expression.Methods Expression of MMP-9 and E-cad in 15 normal tissue specimens,30 specimens of Insulinoma and 50 specimens of pancreatic cancer was determined by immunohistochemical staining,and relationship between MMP-9 and E-cad expression and pathological features in pancreatic cancer.Results The positive rate of MMP-9 and E-cad 82%,24%.The expression of MMP-9 and in the tissue of pancreatic cancer was significantly higher than that in Insulinoma and normal pancreas.The expression of E-cad in the tissue of pancreatic cancer was significantly lower than that in Insulinoma and normal pancreas（P0.05）.The expression of MMP-9 and E-cad protein was associated with lymphatic metastasis and pathological types（P0.05）.The expression of MMP-9 and E-cad protein were negative correlated in pancreatic cancer（P0.05）.Conclusion MMP-9 and E-cad proteins play a critical role in tumor metastasis.Co-detection of the expression of MMP-9 and E-cad can be used to predict the metastatic potential of Pancreatic Cancer,and can effectively evaluate the prognosis of patients with pancreatic cancer.

关 键 词：胰腺癌 上皮钙粘附蛋白 基质金属蛋白酶-9 免疫组化 

分 类 号：R735.9[医药卫生—肿瘤]