慢性乙型肝炎肝内胆汁淤积性黄疸发病机制的研究概况  

The research advancement of pathogenesis of intrahepatic cholestasis jaundice related to chronic hepatits B

作　　者：杨宗国[1] 陈晓蓉[1] 刘成[1] 

机构地区：[1]上海市公共卫生临床中心,上海201508

出　　处：《临床肝胆病杂志》2011年第12期1323-1326,共4页Journal of Clinical Hepatology

基　　金：中医药防治艾滋病;病毒性肝炎等疾病临床科研一体化技术平台体系构建及应用研究(2009ZX10005-019)

摘　　要：慢性乙型肝炎致肝内胆汁淤积性黄疸的发病机制极其复杂,其中肝细胞凋亡、氧化应激及脂质过氧化、巨噬细胞介导的炎症反应等途径均参与肝内胆汁淤积性黄疸的发病。明确肝内胆汁淤积性黄疸的发病机制对临床靶点治疗有重要意义。The pathogenesis of intrahepatic cholestasis jaundice caused by chronic hepatits B is extremely complicated, and the following pathways such as hepatocytes apoptosis, oxidative stress, lipid peroxidation and inflammatory response mediated by macrophage have a close link with the pathogenesis of intrahepatic cholestasis jaundice. To have a clear and complete definition on the pathogenesis of intrahepatic eholestasis jaundice is of great significance for its clinical target therapy.

关 键 词：肝炎 乙型 慢性 胆汁淤积 肝内 细胞凋亡 

分 类 号：R714.2[医药卫生—妇产科学]