网孔型纳米羟基磷灰石/聚酰胺66复合血管内皮细胞生长因子缓释微球治疗早期股骨头缺血坏死的实验研究  

Nano-Hydroxyapatite/Polyamide 66 Biocomposites Combined with Vascular Endothelial Growth Factor for Treating Early Avascular Necrosis of Femoral Head

作　　者：陈诚[1] 梁熙[1] 黄伟[1] 胡宁[1] 尹世杰[1] 杨明明[1] 

机构地区：[1]重庆医科大学附属第一医院骨科,重庆400016

出　　处：《中国药业》2011年第23期4-6,共3页China Pharmaceuticals

基　　金：重庆市自然科学基金;项目编号:CSTC2007BB5291

摘　　要：目的探讨网孔型纳米羟基磷灰石/聚酰胺66(n-HA/PA66)支撑棒复合血管内皮细胞生长因子(VEGF)缓释微球后治疗兔股骨头早期缺血性坏死的效果。方法将复合血管内皮细胞生长因子缓释微球的n-HA/PA66支撑棒植入兔早期股骨头缺血坏死模型,术后3,6,12周时行影像学及组织切片观察。结果复合血管内皮细胞生长因子缓释微囊的n-HA/PA66支撑棒与单纯n-HA/PA66支撑棒治疗效果比较,影像学检测无明显差异,组织染色显示前者有更多的新生骨长入n-HA/PA66支撑棒。结论血管内皮细胞生长因子缓释微囊能增强植入n-HA/PA66支撑棒治疗早期股骨头缺血坏死的骨修复过程。Objective To observe the effect of porous n-HA/PA66 rods combined with vascular endothelial growth factor（VEGF） for the treatment of early stage avascular necrosis of femoral head in rabbits.Methods Implant n-HA/PA66 supporting stick and VEGF microcapsule into the rabbit models of ischemic necrosis of femoral head.Results were evaluated by radiograph and histology at the end of 3rd,6th and 12th week after operation.Results There is no significant difference of radiograph after combination of VEGF.More cancellous bone grew into cage in the group combined with VEGF through staining observation.Conclusion It shows that the composite of VEGF is active in new bone formation and vascular remodeling.

关 键 词：血管内皮细胞生长因子 纳米羟基磷灰石/聚酰胺66 股骨头缺血坏死 骨修复 

分 类 号：R945[医药卫生—微生物与生化药学] R68[医药卫生—药剂学]