艾迪联合化疗对晚期大肠癌患者免疫功能及生活质量的影响  

Effects of Aidi Injection Combined with Chemotherapy on Immune Function and Life Quality of Advanced Colorectal Cancer Patients

作　　者：海艳洁[1] 鞠宝玲[2] 杜萍 卢林[1] 王志强[1] 赵秀峰[1] 周宏博[1] 崔虎军[1] 郝志英[1] 

机构地区：[1]牡丹江医学院红旗医院,黑龙江牡丹江157011 [2]牡丹江医学院病原生物教研室

出　　处：《中国药师》2011年第11期1634-1636,共3页China Pharmacist

基　　金：黑龙江省教育厅科研课题(编号:11553119)

摘　　要：目的:研究艾迪注射液联合化疗对晚期大肠癌患者细胞免疫及生活质量的影响。方法:64例晚期大肠癌患者随机分为治疗组和对照组各32例,治疗组采用艾迪注射液联合FOLFOX4方案化疗;对照组单纯化疗,方案同治疗组。4周后,分别观察两组化疗前后机体免疫状态(CD_3^+、CD_4^+、CD_8^+、CD_4^+/CD_8^+)的变化。并分别观察两组患者治疗前后中医症状评分,KPS评分,食欲及体重方面的变化。结果:治疗组较对照组CD_8^+明显下降,CD_4^+/CD_8^+比值显著上升(P<0.05)。两组患者中医症状评分、karnofsky评分、食欲及体重方面比较,差异有统计学意义(P<0.05)。结论:艾迪注射液可调节大肠癌患者细胞免疫功能,联合化疗可改善晚期大肠癌患者体力状况,提高患者生活质量。Objective： To observe the effect of Aidi injection combined with chemotherapy on immune function and life quality in advanced colorectal cancer patients. Method： Sixty-four advanced colorectal cancer patients were randomly divided into two groups. The treatment group with 32 patients was treated with Aidi injection and chemotherapy. The control group with the other 32 patients was trea- ted with chemotherapy only. The two groups were both given FOLFOX4 treatment protocols. After 4 weeks, the changes in body immune state （CD3＋ , CD4＋ , CDs and CD4/CD8＋ ） ,TCM symptom score, KPS, body weight and appetite before and after the treatment were ob- served. Result： Compared with that of the control group, CDs of the treatment group was significantly decreased while the ratio of CD4＋/CD8＋ was significantly increased after the chemotherapy （P 〈 0. 05 ）. There were significant differences in TCM symptom score, KPS, body weight and appetite between the two groups （P 〈 0.05）. Conclusion： Aidi injection can enhance immune function and im- prove life quality indeed which is valid to advanced colorectal cancer patients.

关 键 词：艾迪注射液 大肠癌 化疗 细胞免疫 生活质量 

分 类 号：R286[医药卫生—中药学]