丹墨胶囊质量标准研究  

Study on the Quality Standard of Danmo Capsule

作　　者：李瑞明[1] 陈孝[1] 林生文[1,2] 隆颖[2] 曹媛[1] 吴敏江[1] 任斌[1] 

机构地区：[1]中山大学附属第一医院,广东广州510080 [2]广东省药品检验所,广东广州510180

出　　处：《中药材》2011年第10期1618-1621,共4页Journal of Chinese Medicinal Materials

基　　金：广州市重大科技专项计划项目(2008A1-E4101-7);广东省自然科学基金面上项目(8151008901000167);广东省中医药局课题(2009159);广东省医院药学研究基金(2010A15)

摘　　要：目的:建立丹墨胶囊的质量标准。方法:采用薄层色谱法对方中丹参、金银花进行定性鉴别,采用高效液相色谱法对丹酚酸B进行含量测定。结果:TLC斑点清晰、分离度好,阴性对照无干扰;丹酚酸B进样量在0.120042～2.40084μg范围内与峰面积积分值呈良好的线性关系(r=0.9999),平均回收率为103.63%,RSD为0.6%(n=6)。结论:该方法操作简便,结果准确、可靠,所建标准可用于该制剂的质量控制。Objective：To establish the quality standard for I）anmo capsule. Methods：TLC was used for the qualitative identification of Salviae Miltiorrhizae Radix Et Rhizoma and Lonicerae Japonicae Flos. HPLC was used to determine the content of Salvianolic acid B. Result： TLC spots were clear and well-separated without negative interference. The linear range of Salvianolic acid B was 0. 120042 -2.40084μg（ r = 0. 9999）with an average recovery of 103.63% , RSD was 0. 6% （n=6）. Conclusion ：The method is simple,accurate and reliable. It can be used for the quality control of Danmo capsule.

关 键 词：丹墨胶囊 丹参 金银花 质量标准 丹酚酸B 

分 类 号：R286.1[医药卫生—中药学]