ZTC1+1Ⅲ絮凝澄清剂用于防感喷雾剂精制工艺的优选研究  

The Effects of ZTC1+1 Ⅲ Flocculation Agent on the Refining Technology of Anti-flu Spray

作　　者：王泽锋[1,2] 侯安国[1] 李甲英[1] 李安华[1] 

机构地区：[1]云南中医学院,云南昆明650500 [2]云南省红河学院,云南蒙自661100

出　　处：《儿科药学杂志》2011年第6期44-46,共3页Journal of Pediatric Pharmacy

基　　金：云南省科技厅重点新产品开发计划项目(2008IF014)

摘　　要：目的:优选ZTC1+1Ⅲ絮凝澄清剂用于防感喷雾剂的精制工艺条件。方法:以吸光度作为评价指标,筛选出ZTC1+1Ⅲ絮凝澄清剂对各个因素的影响范围,再以连翘苷转移率和总苷保留率作为评价指标,采用L9(34)正交实验优选防感喷雾剂最佳精制工艺。结果:影响因素大小依次是:ZTC1+1Ⅲ絮凝澄清剂加入量(B)>搅拌速度(C)>药液浓度(A)。最佳工艺条件为将药液浓缩至生药∶药液=1.04∶5(g/mL),ZTC1+1Ⅲ絮凝澄清剂加入量为B/A(0.12 g∶0.06 g)/10.4 g(按生药量计算),搅拌速度400 r/min。结论:ZTC1+1Ⅲ絮凝澄清剂澄清效果好,经济实用,可用于防感喷雾剂的精制工艺。Objective： To study the flocculation process with ZTC1＋1 Ⅲ for Anti-flu Spray.Methods： The contents of forsythin and total glycosides were chosen as the assessment index.The optimum conditions were selected by the L9（34） of orthogonal experiment.Results： The influence factors were in order of the amount of ZTC1＋1 Ⅲ（B）,stirring rate（C） and the concentration of the extracting solution（A）.The optimal flocculation process condition was A1B3C3.The medicinal materials and extract solution were 1.04∶5（g/mL）.The adding amount of ZTC1＋1 Ⅲ was B/A（0.12 g∶0.06 g）/10.4 g,and the stirring speed was 400 r/min.Conclusions： The flocculation process with ZTC1＋1 Ⅲ is effective and economic for the clarification and can be used for the purification of Anti-flu Spray.

关 键 词：防感喷雾剂 ZTC1+1Ⅲ絮凝澄清剂 正交设计 连翘苷 

分 类 号：R284[医药卫生—中药学]