诱导型环氧合酶高表达增加兔主动脉粥样硬化斑块易损性  

Overexpression of COX-2 enhances rabbit atherosclerotic plaque vulnerability

作　　者：李岚[1] 樊民[2] 倪灿荣[3] 梁春[2] 任雨笙[2] 吴宗贵[2] 

机构地区：[1]解放军第411医院内四科,上海200081 [2]第二军医大学长征医院心内科,上海200003 [3]第二军医大学长海医院病理科,上海200433

出　　处：《心脏杂志》2011年第6期715-718,共4页Chinese Heart Journal

基　　金：上海市卫生局科研基金项目资助(2007105)

摘　　要：目的:探讨诱导型环氧合酶(COX-2)在兔主动脉粥样硬化(atherosclerosis,AS)组织中的表达及其与斑块易损性之间的关系。方法:以高脂饲料喂养建立兔主AS模型,并与正常饲料组对照。喂养12周后,取兔主动脉标本,行HE及免疫组化染色,观察COX-2、基质金属蛋白酶-2(MMP-2)、Ⅰ型和Ⅲ型胶原在AS斑块组织中的表达。结果:COX-2仅见于AS斑块,正常动脉壁无表达。AS组COX-2免疫组化染色强度均显著高于正常对照组(P<0.05)。AS组Ⅰ、Ⅲ型胶原和MMP-2免疫组化染色强度均显著高于正常对照组(P<0.05),Ⅰ/Ⅲ型胶原的比例增加。结论:COX-2在兔主动脉AS斑块中的高表达可能增加斑块的易损性。AIM： To evaluate the expression of COX-2 in rabbit atherosclerotic plaque and the relationship between COX-2 and plaque vulnerability.METHODS： The rabbit aortic atherosclerotic model was developed by high cholesterol feeding.Rabbit aorta specimens were measured by HE staining and immunohistochemical staining of COX-2,MMP-2 and I/III collagen.RESULTS： COX-2 was found in atherosclerotic plaques but not in healthy or nonatherosclerotic vascular walls.COX-2,MMP-2 and I/III collagen was induced in atherosclerotic plaque lesions,implicating a relationship between COX-2 and plaque vulnerability.CONCLUSION： Overexpression of COX-2 enhances rabbit atherosclerotic plaque vulnerability.

关 键 词：动脉粥样硬化 诱导型环氧合酶 斑块 易损性 

分 类 号：R543.12[医药卫生—心血管疾病]