胺碘酮与胺碘酮联合用药治疗心房纤颤疗效的比较  

Comparative effect of amiodarone and amiodarone combined with other drugs in treatment of atrial fibrillation

作　　者：陈士良 辛卫鹏[2] 高谊[2] 

机构地区：[1]舟山市医院心内科,浙江舟山316000 [2]南方医科大学临床医学系,广东广州510515

出　　处：《心脏杂志》2011年第6期779-781,共3页Chinese Heart Journal

基　　金：全军医药卫生科研课题资助(06MA366)

摘　　要：目的:观察单纯用药与联合用药对心房纤颤(房颤)治疗效果。方法:选择119例房颤患者随机分为2组:单纯用药组54例,给予静脉胺碘酮150～300 mg后,继之以口服胺碘酮维持;联合用药组65例,使用极化液、硝酸甘油和小剂量利尿剂、胺碘酮,胺碘酮使用的剂量与方法同单纯用药组。观察两组房颤转复率和窦性维持率。结果:联合用药组的房颤转复率较单纯组明显提高(80%vs.94%,P<0.05),复律时间减少[(55±19)vs.(39±15)s,P<0.05],追踪复律半年后的维持率,联合用药组明显高于单纯用药组(81%vs.95%,P<0.05)。复查B超显示:联合用药后,左心房内经明显缩小,从[(46±6)mm减少到(42±6)mm,P<0.05],左心室舒张末期内径缩小,从(52±7)mm减少到(45±6)mm(P<0.05);而单纯用药组这两项指标均无明显改变。结论:联合用药组较单纯用药组能明显提高对房颤患者的转复率和窦性维持率。AIM： To compare the effect of amiodarone alone and amiodarone combined with other drugs in treatment of atrial fibrillation（AF）.METHODS： A total of 119 patients with AF were divided into single drug group（n=54） and multiple drug group（n=65）.The single drug group received amiodarone treatment,whereas the multiple drug group received treatment of amiodarone together with glucose-insulin-potassium and diuretics.The recovery rate of AF and the maintenance rate of sinus rhythm were observed and compared after 6 months treatment.RESULTS： A significant increase in the recovery rate（from 80% vs.94%） and a significant decrease in the recovery duration of sinus rhythm from（55±19） h to（39±15） h were observed in the multiple drug group.The maintenance rate increased from 81% to 95%,left atrial diameter decreased from（46±6） mm to（42±6） mm and the left ventricular diastolic diameter decreased from（52±7） mm to（45±6） mm in the multiple drug group.However,these phenomena were not seen in the single drug group.CONCLUSION： Compared with amiodarone alone,amiodarone combined with other drugs significantly increases the recovery rate and the maintenance rate in patients with AF.

关 键 词：心房纤颤 治疗 胺碘酮 极化液 利尿剂 

分 类 号：R541.75[医药卫生—心血管疾病]