β1肾上腺素能受体基因Arg389Gly多态性与原发性高血压关联的荟萃分析  

Polymorphisms of Arg389Gly of β1-adrebergic receptor gene and essential hypertension risk： a meta analysis

作　　者：李雅洁[1] 李霓[2] 杨琳[2] 李永旺[1] 丁旭[1] 赵洪涛[1] 李颖[1] 

机构地区：[1]大连市中心医院综合二科,116033 [2]中国医学科学院北京协和医学院肿瘤医院全国肿瘤防治研究办公室

出　　处：《中华医学杂志》2011年第44期3115-3119,共5页National Medical Journal of China

摘　　要：目的系统评价β1肾上腺素能受体基因Arg389Gly多态性与原发性高血压的易感关联。方法在美国国立医学图书馆数据库（PubMed），中国学术期刊网全文数据库（CNKI）和万方数据库中，查询1990年1月至2011年6月所有相关文献及其引文。根据对各研究结果进行异质性检验的结果，选择固定或随机效应模型进行数据合并，并采用Egger’s和Begg’s检验进行发表偏倚的评估。结果本研究获得13篇符合要求的病例一对照研究，共计病例6429例，对照6986名。总体而言，各研究问异质性较大（Q=37．32，P〈0．001）。按样本量分层后可见，在病例数t〉500例组中，与Arg／Arg基因型携带者相比较，Gly／Gly基因型携带者原发性高血压罹患易感性显著性降低（OR=0．84，95％CI为0．73～0．98），且研究间无异质性（Q=1．10，P=0．777）；Arg／Gly基因型携带者原发性高血压罹患易感性界值降低（OR=0．95，95％CI为0．91—1．00）。显性模型结果证实，与Arg／Arg基因型携带者相比较，Arg／Gly和Gly／Gly基因型携带者，原发性高血压罹患易感性显著降低（OR=0．95，95％CI为0．91～0．99）。结论Arg389Gly多态性可能与原发性高血压易感性相关，Arg／Arg基因携带者可能增加罹患原发性高血压的风险。Objective To evaluate the associations between polymorphisms Arg389Gly of β1-adrebergic receptor gene and essential hypertension risk. Methods ＂Hypertension＂, ＂polymorphism＂, ＂Arg389Gly＂ and ＂betal-adrenergic＂ or ＂ betal-adrenoceptor＂ were used as key words to search the relevant publications between January 1990 and June 2011 in the databases of Pubmed, CNKI and Wanfang. Additional references cited in the retrieved articles were also evaluated. Between-study heterogeneity test was performed by the X2-based Q test. Fix/random-effect model was used for data pooling. Publication bias was evaluated with the linear regression asymmetry Egger＇s and Begg＇s tests. Results Fourteen case-control studies containing 6429 cases of essential hypertension cases and 6986 controls were included for the analyses of Arg389G1y and risk of essential hypertension. Between-study heterogeneity was significant across all studies（ q = 37. 32, P 〈0. 001 ）. After stratification by sample size, among the sub-group with a sample size of over 500 cases, the Gly/Gly carriers had significantly a lower risk of essential hypertension than the Arg/Arg carriers （ OR = 0. 84, 95 % CI 0. 73 - 0. 98 ）. There was no between-study heterogeneity （ q = 1.10, P = 0. 777 ）. In addition, the risk borderline decreased in the Arg/Gly carriers（ OR = 0. 95, 95% CI 0. 91 - 1.00）. The results of dominant model also showed that the risk of essential hypertension significantly decreased（ OR = 0.95, 95% CI 0. 91 -0.99 ）among the Arg/Gly and Gly/Gly carries versus the Arg/Arg carriers. Conclusion The Arg389Gly Arg/Arg genotype carriers are associated with an elevated risk of essential hypertension. And Arg389Gly of β1-adrebergic receptor gene may play a role in the susceptibility of essential hypertension.

关 键 词：高血压 基因 META分析 

分 类 号：R544.1[医药卫生—心血管疾病]