重度慢性心力衰竭患者血清BNP水平变化及临床分析  

Clinical Analysis of the Change of Plasma BNP Levels in Patients with Severe Chronic Heart Failure

作　　者：郑硕[1] 方坤[1] 穆易[1] 马艳[1] 

机构地区：[1]淮南新康医院心内科,安徽淮南232007

出　　处：《亚太传统医药》2011年第12期89-90,共2页Asia-Pacific Traditional Medicine

摘　　要：目的:探讨重度慢性心力衰竭患者血浆B型尿钠肽(BNP)的改变及临床意义。方法:选择我院2009年3月-2011年3月收治的重度慢性心力衰竭患者58例,其中心功能III级25例,IV级33例,同期健康体检者30例,测定血清BNP浓度、左室射血分数(LVEF),对两组进行比较分析。结果:重度慢性心力衰竭患者血浆BNP水平较正常对照组明显增高(P<0.01),并随心功能恶化,血浆BNP水平升高,LVEF下降。抗心力衰竭药物综合治疗后,血浆BNP水平明显降低(P<0.05)。结论:血浆BNP水平的检测可作为临床判断心衰的有效指标,对心衰的预后有重要的意义。Objective：To study the clinical significance of the change of plasma BNP levels in the patients with severe chronic heart failure.Methods： From March 2009 to March 2011 in our hospital,the plasma BNP levels and LVEF of 58 patients with severe chronic heart failure（25 III grade,33 IV grade） and 30 healthy subjects during the same period were determined.The results were compared and analyzed.Results： The plasma BNP levels of severe chronic heart failure patients was significantly higher than that of the healthy subjects（P0.01） and increased with severity along with decreasing LVEF.After a course of treatment,the plasma BNP levels were significantly lower than those before therapy（P0.05）.Conclusion： Measuring of plasma BNP level might be a effective clinical markers in evaluation of heart failure,and for monitoring the progress of heart failure.

关 键 词：心力衰竭 血浆 B型尿钠肽 

分 类 号：R541.6[医药卫生—心血管疾病]