鼻内镜下经咽鼓管鼓室内置管注药治疗梅尼埃病  

Intratympanic Gentamicin through an inserted catheter for Meniere′s disease

作　　者：于海洋[1] 孙丰林[1] 张增[1] 王卫国[1] 

机构地区：[1]淄博市中心医院耳鼻咽喉-头颈外科,山东淄博255031

出　　处：《山东大学耳鼻喉眼学报》2011年第6期64-66,共3页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：目的观察鼓室内置管注入庆大霉素治疗梅尼埃病的疗效。方法在鼻内镜引导下经咽鼓管向鼓室内置入硬膜外麻醉导管,留置1周左右,期间注入庆大霉素注射液,并同期口服类固醇激素以保护听力。观察用药后1、3、7 d及3个月后的疗效。结果庆大霉素注射后1 d内即可缓解患者眩晕症状,1周内症状完全缓解,3个月内复发率极低。结论既往大多数实验集中在庆大霉素对内耳细胞损伤作用的研究,而忽视了其治疗作用,我们认为内耳灌注氨基糖苷类抗生素可以有效治疗梅尼埃病。Objective To treat meniere＇s disease by intratympanic gentamicin through an inserted catheter and to ex- plore its effect. Methods A catheter was put into the tympanum through an eustachina tube under nasal endoscopic vi- sualization and it was kept for almost one week. Gentamicin was injected after insertion of catheters into the tympanum and oral steroid hormone was used to protect audition. Patients were observed on the first day, the third day, the sev- enth day and in three months. Results After injection of gentamicin, vertigo was relieved the next day, and complete- ly relieved within a week while the recurrence rate was extremely low. Conclusion Most of retrospective experiments have focused on research about the damage effect of gentamicin to the inner ear ceils without paying attention to its ther- apeutic effect. It was found that it is effective to cure meniere＇s disease by intratympanic aminoglycosides antibiotics.

关 键 词：梅尼埃病 庆大霉素 鼻内镜检查 

分 类 号：R764.33[医药卫生—耳鼻咽喉科] R978.12[医药卫生—临床医学]