血清脂蛋白(a)和视黄醇结合蛋白4与2型糖尿病视网膜病变的相关性  

Association of serum lipoprotein(a) level,retinol-binding protein 4 with diabetic retinopathy in type 2 diabetes

作　　者：田婷[1] 马向华[1] 沈捷[1] 

机构地区：[1]南京医科大学第一附属医院内分泌科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2011年第11期1620-1622,1652,共4页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省卫生重点学科基金(XK200701)

摘　　要：目的:探讨2型糖尿病视网膜病变发生的独立危险因素。方法:选取南京医科大学第一附属医院内分泌科2009年1月～2010年12月82例糖尿病视网膜病变患者和86例不伴有视网膜病变的2型糖尿病患者进行病例-对照研究。比较两组临床参数及生化指标,对于有意义的指标进一步行Logistic回归分析,寻找糖尿病视网膜病变的独立预后指标。结果:单变量分析结果显示,两组间糖尿病病程、糖化血红蛋白、舒张压及视黄醇结合蛋白4(retinol-binding protein 4,RBP4)有统计学差异。Lo-gistic回归分析显示:糖尿病病程(OR=2.41;95%CI:1.12～5.18)、脂蛋白(a)(OR=2.22;95%CI:1.15～4.31)和RBP4(OR=2.95;95%CI:1.54～5.65)是糖尿病视网膜病变发生的独立预测指标。结论:脂蛋白(a)和RBP4是糖尿病视网膜病变发生的危险因素,且为独立的预测因子。Objective： To investigate the independent risk factors related to the development of diabetic retinopathy（DR） for type 2 diabetic patients.Methods： A case-control study containing 82 DR patients and 86 diabetics patients without DR（NDR） was performed from January,2009 to December,2010.The clinical parameter and biochemical indicators were compared between the two groups.Conditional Logistic regression analysis was further performed to assess variables independently associated with the DR developing.Results： In the univariate analysis,duration of diabetes,HbA1c,diastolic blood pressure and retinol-binding protein 4（RBP4） were significant between DR and NDR.Logistic regression analysis showed that duration of diabetes（OR=2.41;95%CI：1.12～5.18）,lipoprotein（a）（OR=2.22;95% CI：1.15～4.31） and RBP4（OR=2.95;95% CI：1.54～5.65） were significant and independent predictors of the DR developing.Conclusion： These data suggest that duration of diabetes,lipoprotein（a） and RBP4 level are independent risk factors for the development of DR in type 2 diabetics.

关 键 词：糖尿病视网膜病变 脂蛋白(a) 视黄醇结合蛋白-4 危险因素 

分 类 号：R587.1[医药卫生—内分泌]