输卵管组织LIF及其受体LIFR的表达与输卵管妊娠的关系  

The correlation between the occurrence of tubal pregnancy and the expression levels of LIF and LIFR in oviduct tissues

作　　者：李咏[1,2] 孙丽洲[1] 赵丹梅[2] 欧阳俊[3] 向梅[2] 马文琴[2] 吴超英[2] 史文忠[2] 唐正华[3] 

机构地区：[1]南京医科大学第一附属医院妇产科,江苏南京210029 [2]南京医科大学附属常州市妇幼保健院普妇科,江苏常州213003 [3]南京医科大学附属常州市妇幼保健院病理科,江苏常州213003

出　　处：《南京医科大学学报（自然科学版）》2011年第11期1663-1666,共4页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省自然科学基金(BK2010583);常州市科技局科研基金资助(CS20092013)

摘　　要：目的:探讨白血病抑制因子(LIF)及其受体(LIFR)与输卵管异位妊娠的关系。方法:采用免疫组化技术检测11例非孕组和36例输卵管异位妊娠组输卵管组织中LIF和LIFR的表达水平,半定量分析其在各组间的表达差异。结果:无论是在输卵管腺上皮还是间质中,LIF在非孕组和异位妊娠组间的表达无明显差别;但是在输卵管腺上皮中,LIFR的表达异位妊娠组高于非孕组(P<0.05);而在间质中,LIFR的表达输卵管妊娠组明显低于非孕组(P<0.01)。结论:LIFR的异常表达可能与输卵管异位妊娠的发生密切相关。Objective： To explore the correlation between the occurrence of tubal pregnancy and the expression level of leukemia inhibitory factor（LIF） and LIF receptor（LIFR）.Methods： Semi-quantitative analysis of LIF and LIFR by immunohistochemistry was performed in 11 fallopian tubal tissues of non-pregnant group,and 36 of tubal pregnancy group,respectively.Results： The LIFR expression level in fallopian tubal epithelium cells of tubal pregnancy group was significantly higher than that of non-pregnant group.While the LIFR abundance in interstitial cells of tubal pregnancy group was significantly lower than that of non-pregnant group.However,no significant difference of LIF abundance was found between two groups.Conclusion： Aberrant expression of LIFR in oviduct tissues might be involved in the ectopic implantation process of tubal pregnancy.

关 键 词：输卵管妊娠 白血病抑制因子 白血病抑制因子受体 

分 类 号：R714.22[医药卫生—妇产科学]