可溶性内皮因子的水平变化与子痫前期发病的关系  

Relationship between alterations of soluble endoglin in maternal serum and pathogenesis of patients with preeclampsia

作　　者：魏梓雯[1] 张爱红 张一鸣[1] 袁小松[1] 蒋丽霞[1] 

机构地区：[1]南京医科大学附属常州市妇幼保健院检验科,江苏常州213003 [2]南京白敬宇制药有限责任公司,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2011年第11期1667-1669,共3页Journal of Nanjing Medical University(Natural Sciences)

基　　金：常州市卫生局资助项目(WZ201028)

摘　　要：目的:检测正常妊娠与子痫前期患者不同孕周的血清可溶性内皮因子(soluble endoglin,sEng)水平,探讨其在子痫前期发病中的作用。方法:检测并比较31例轻度子痫前期患者、26例重度子痫前期患者及43例正常妊娠妇女sEng的血清学水平。结果:孕12～16周、孕20～24周、孕28～32周、孕37～41周,sEng在正常妊娠组浓度为(7.7±1.5)、(8.2±1.6)、(9.3±1.7)、(11.4±2.6)ng/ml;轻度子痫前期组为(7.8±1.5)、(9.4±1.8)、(14.2±2.9)和(21.1±3.7)ng/ml;重度子痫前期组为(7.9±1.6)、(12.5±2.8)、(25.2±3.9)、(33.6±4.5)ng/ml。除孕12～16周,各组sEng水平差异无显著性意义(P>0.05);孕20～24周、孕28～32周、孕37～41周,轻度与重度组sEng水平均显著高于正常妊娠组水平(P<0.01)。结论:孕妇血清中sEng水平变化与子痫前期发病及病情发展有关。Objective: To detect serum levels of soluble endoglin(sEng) during different periods in normal pregnancy and patients with preeclampsia and evaluate its role in the pathogenesis of preeclampsia.Methods: Women were enrolled in following groups:healthy pregnant control(n = 43) and preeclampsia patients,which contained mild preeclampsia(n = 31),severe preeclampsia(n = 26).The serum sEng levels were measured by enzyme linked immunoassay(ELISA).Results: The concentration of sEng in control group during 12～16,20～24,28～32 and 37～41 weeks were(7.7 ± 1.5),(8.2 ± 1.6),(9.3 ± 1.7) and(11.4 ± 2.6) ng/ml,respectively.They were(7.8 ± 1.5),(9.4 ± 1.8),(14.2 ± 2.9),(21.1 ± 3.7) ng/ml in mild preeclampsia group,and(7.9 ± 1.6),(12.5 ± 2.8),(25.2 ± 3.9),(33.6 ± 4.5) ng/ml in severe preeclampsia group,respectively.The levels of maternal plasma sEng were significantly higher in the preeclamptic women than in normal controls during the latter three periods(P < 0.01) except for the first period.Conclusion: Alterations in the levels of sEng in maternal serum were associated with the occurrence and development of preeclampsia.

关 键 词：子痫前期 可溶性内皮因子 

分 类 号：R714.24[医药卫生—妇产科学]