江苏省2008年自然人群麻疹血清流行病学特征分析  

Analysis on Seroepidemiological Characteristics of Measles in Jiangsu Province,2008

作　　者：贾成梅[1] 陶红[1] 丁晓燕[1] 陆培善[1] 刘元宝[1] 黄红玉[1] 马福宝[1] 

机构地区：[1]江苏省疾病预防控制中心,南京210009

出　　处：《中国初级卫生保健》2011年第12期68-70,共3页Chinese Primary Health Care

摘　　要：目的了解2008年江苏省自然人群的麻疹抗体水平,评价人群麻疹免疫力状况,为调整免疫策略提供依据。方法采用分层整群抽样法,抽取苏州市的昆山市、张家港市、泰州市的泰兴市和淮安市的楚州区<8月龄、8月龄～2岁、3～14岁、15～19岁、20～29岁、30～39岁和≥40岁4 621人,用酶联免疫吸附试验对其麻疹抗体进行检测。结果人群麻疹IgG抗体总阳性率为88.73%,几何平均浓度(Geometric Mean Concentration,GMC)为803.18 mIU/mL。不同年龄、不同地区人群麻疹抗体阳性率和GMC差异均有统计学意义。抗体阳性率最高的为3～14岁(97.81%);其次为≥15岁,抗体阳性率均>90%;较低的为8月龄～2岁(89.73%);<8月龄婴儿最低(19.95%)。GMC最高的是3～14岁(1 221.32 mIU/mL),<8月龄婴儿最低(57.16 mIU/mL)。苏南地区的昆山市、张家港市麻疹抗体阳性率和GMC均高于苏北的淮安市楚州区和泰兴市。结论 2008年江苏省自然人群麻疹抗体总阳性率低于消除麻疹队列人群免疫力95%的指标,应提高儿童常规免疫接种率和及时接种率,适时开展强化免疫。OBJECTIVE To analyze the seroepidemiological characteristics of measles in Jiangsu province and provide evidence for strategies and measures of measles elimination. METHODS 4 621 persons were randomly selected from the counties of Kunshan, Zhangjiagang, Taixing and Chuzhou. The sera were tested and interpreted, using cerman virion-serion anti-measles IgG enzyme immunoassay. RESULTS The positive rate of measles antibody was 88.73% and the geometric mean concentration （GMC）was 803.18 mlU/mL. The differences of positive rate and GMC among age groups and counties were statistically significant. The distribution of positive rate about measles antibody in different age groups is as follows： 3-14 years 97.81%, ≥ 15 years more than 90%, 8 months-2 years 89.73%, 〈8 months 19.95%. The highest GMT of measles antibody is 1 221.32 mIU/mL in 3-14 years and the lowest is 57.16 mIU/mL in 〈8 months. Both the positive rate and GMT of measles antibody are higher in the south region than in the north region. CONCLUSIONS Though the total level of immunity against measles is high in these counties, it is extremely challenging to achieve 95% immunity about measles elimination. In order to carry out this target, the timeliness and coverage of childhood vaccinations must be improved. Measles vaccine supplementary immunization activities should be conducted at suitable time as well.

关 键 词：麻疹 自然人群 血清流行病学 

分 类 号：R511.1[医药卫生—内科学]