肟基苯乙酮合成工艺优化研究  

Optimization of Synthesis Technology of Oximido-acetophenone

作　　者：朱平华[1] 陈文宾[1] 

机构地区：[1]淮海工学院化学工程学院,江苏连云港222005

出　　处：《湖北农业科学》2011年第22期4612-4613,4616,共3页Hubei Agricultural Sciences

基　　金：教育部重点实验室开放基金资助项目(CPEUKF06-04);淮海工学院江苏海洋资源开发研究院基金资助项目;淮海工学院大学生实验室创新项目

摘　　要：以亚硝酸钠、甲醇、浓硫酸和苯乙酮为原料,氢氧化钠为催化剂通过两步反应合成了肟基苯乙酮。通过正交试验确定最佳合成的工艺条件是亚硝酸钠:甲醇:浓硫酸:苯乙酮=0.8:1.0:0.5:1.0(摩尔比),催化剂的用量10 mL(1.2 mol/L),反应温度5℃。产品的总收率83.1%,纯度99.0%。试验的分析结果表明,反应温度是反应的主要影响因素。Oximido-acetophenone was synthesized from sodium nitrite,methanol,concentrated sulphuric acid and acetophenone with sodium hydroxide as the catalyst by two steps reaction.Best reaction conditions are found by orthogonal test.The optimum conditions were as follows the amount ratio of sodium nitrite,methano,sulfuric acid and acetophenone was 0.8∶1.0∶0.5∶1.0;the amount of catalyst sodium hydroxide was 10 mL（1.2 mol/L）,reaction temperature was 5 ℃.The total yield ratio of products was 83.1%,and the content was 99.0%.Results show that temperature was the main affecting factor.

关 键 词：肟基苯乙酮 合成 优化工艺 正交试验 

分 类 号：TQ244.2[化学工程—有机化工]